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Sci Rep:脑组织缺乏“编辑”是脑癌的潜在驱动因素

2017-06-19 黑衣服的胖子 来宝网

发表在Scientific Reports一篇论文表明:人们对脑癌进展的理解前进了“小而重要”的一步,并提出了通过使用基因组工程技术来减缓或逆转脑癌进展的可能性。



发表在Scientific Reports一篇论文表明:人们对脑癌进展的理解前进了“小而重要”的一步,并提出了通过使用基因组工程技术来减缓或逆转脑癌进展的可能性

MicroRNA是一种不编码蛋白质的特殊类型的RNA分子,但它参与关键的调节功能。他们可以诱导核糖核苷酸针对性的变化 - 这被称为“编辑”的过程。反过来,编辑可以扩大RNA分子的功能,这是对维持细胞多样性和帮助我们的身体适应和不断地进化的至关重要的过程。

环境和生命科学学院人类遗传学和基因组学研究员Arijit Mukhopadhyay博士以及他的同事Dehli同时表示,这些核糖核苷酸在脑癌患者体内不断减少的现象可能是引发脑癌的驱动因素。

Mukhopadhyay博士和他的团队还研究了在13类型人体组织中的正常的microRNA编辑谱,发现健康的大脑具有最高的编辑量,这意味着观察其在脑癌患者中下降的重要性。

“正是发生了什么,我们不能说,但是随着这些编辑事件的水平和位置的改变,细胞产量可以被显着地改变,我们在观察癌症的情况下。”他说。

此外,这项研究也提出了一个问题,我们都可以利用基因组工程技术(如基因编辑技术)去重建“编辑”过程去恢复生物结果的“编辑”过程。

已发表在Nature Scientific Reports论文显示:人类miRNA的A-to-I编辑在人体不同组织的种子序列中是丰富的,其受序列情况的影响,并且在多形性胶质母细胞瘤中显着缺乏。

原始出处:

Deepanjan Paul, Ashis Narayan Sinha, Arjun Ray, et al. A-to-I editing in human miRNAs is enriched in seed sequence, influenced by sequence contexts and significantly hypoedited in glioblastoma multiforme. Scientific Reports, 2017; 7 (1) DOI: 10.1038/s41598-017-02397-6.

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    2017-06-21 luominglian113

    学习了,谢谢分享

    0

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    2017-06-21 yahu
  5. [GetPortalCommentsPageByObjectIdResponse(id=2028383, encodeId=a154202838334, content=<a href='/topic/show?id=ba7e10150e84' target=_blank style='color:#2F92EE;'>#驱动因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101507, encryptionId=ba7e10150e84, topicName=驱动因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun May 13 05:41:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213574, encodeId=f7bf2135e40a, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed Jun 21 18:52:31 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391882, encodeId=f4a81391882af, content=<a href='/topic/show?id=085c8495615' target=_blank style='color:#2F92EE;'>#脑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84956, encryptionId=085c8495615, topicName=脑癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Wed Jun 21 08:41:00 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592046, encodeId=a5aa15920467e, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Wed Jun 21 08:41:00 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213055, encodeId=2a1f21305522, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Tue Jun 20 08:30:52 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213018, encodeId=1dd92130189d, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Jun 20 08:08:33 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212845, encodeId=77c52128450a, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Jun 19 20:30:35 CST 2017, time=2017-06-19, status=1, ipAttribution=)]
    2017-06-20 184****9840

    学习了谢谢分享。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2028383, encodeId=a154202838334, content=<a href='/topic/show?id=ba7e10150e84' target=_blank style='color:#2F92EE;'>#驱动因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101507, encryptionId=ba7e10150e84, topicName=驱动因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, createdName=fengyi812, createdTime=Sun May 13 05:41:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213574, encodeId=f7bf2135e40a, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Wed Jun 21 18:52:31 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391882, encodeId=f4a81391882af, content=<a href='/topic/show?id=085c8495615' target=_blank style='color:#2F92EE;'>#脑癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84956, encryptionId=085c8495615, topicName=脑癌)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQHWdlyPWPmuHjfEXicudmC0dJ6SN5PHzglbDHibXpT1VXF2fKDnTzl2Eib4Pf94p58cnSKA3ZfGdFQ/132, createdBy=c44f2500101, createdName=ms2694732865965676, createdTime=Wed Jun 21 08:41:00 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592046, encodeId=a5aa15920467e, content=<a href='/topic/show?id=c3a68498683' target=_blank style='color:#2F92EE;'>#脑组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84986, encryptionId=c3a68498683, topicName=脑组织)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=819d18073578, createdName=yahu, createdTime=Wed Jun 21 08:41:00 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213055, encodeId=2a1f21305522, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Tue Jun 20 08:30:52 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213018, encodeId=1dd92130189d, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Tue Jun 20 08:08:33 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212845, encodeId=77c52128450a, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon Jun 19 20:30:35 CST 2017, time=2017-06-19, status=1, ipAttribution=)]
    2017-06-20 Y—xianghai

    学习了新知识

    0

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    2017-06-19 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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