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非糖尿病和糖尿病人群的空腹血糖轨迹与骨质疏松风险之间的关联研究

2023-10-04 美年健康研究院 美年健康研究院 发表于陕西省

该研究旨在调查FPG轨迹与非糖尿病和糖尿病人群骨质疏松风险之间的关联。

2022年11月,北京大学公共卫生学院和美年健康研究院共同在英文期刊" Frontiers in Public Health "上发表了一篇题为" Association between trajectories of fasting plasma glucose and risk of osteoporosis in non-diabetic and diabetic populations "的研究论文。该研究旨在调查FPG轨迹与非糖尿病和糖尿病人群骨质疏松风险之间的关联。

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糖尿病,特别是2型糖尿病(T2DM),是一种常见的代谢性疾病,在全球范围内的疾病负担不断增加。T2DM患者患心脏病的风险比正常糖尿病人群高出40%至70%。

骨质疏松,是脆性缺血的主要原因,其特征是骨量低和骨组织结构恶化。然而,既往研究利用单一时点空腹血糖(FPG)来分析其与骨质疏松风险之间的关联,所得到的结论并不一致。不考虑FPG随时间的变化和累积平均值,可能会使FPG与骨质疏松之间的真实关联产生偏倚。

为了探讨FPG轨迹与非糖尿病和糖尿病人群骨质疏松风险之间的关联,研究员使用了2008—2018年北京美兆体检中心参加体检的18,313名体检者数据,开展了一项大规模的横断面研究。

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体检者在第一次体检时无骨质疏松,随访直到2018年12月31日前的最后一次体检为止。研究记录了体检者随访期间内至少三个FPG值。体检者的纵向FPG轨迹通过潜类别增长分析模型确定。使用多变量逻辑回归模型分析非糖尿病患者和糖尿病患者FPG轨迹与骨质疏松症发病风险之间的关联。

在16,966名非糖尿病者中发生了752例骨质疏松,在1,347名糖尿病者中发生了57例骨质疏松。在非糖尿病者中,FPG轨迹升高与女性骨质疏松风险呈显著负相关关联(OR: 0.62, 95% CI: 0.43-0.88)。在绝经前女性中,FPG轨迹升高者比FPG轨迹正常者的骨质疏松风险更低(OR,0.41;95% CI,0.20–0.88),但这一关联在绝经女性中并不显著。在糖尿病者中,与保持稳定的中高水平FPG患者相比,FPG轨迹保持在非常高水平者发生骨质疏松症的风险最高(OR: 3.09, 95% CI: 1.16-8.22),而FPG以高水平开始持续增加者的骨质疏松风险并没有显著增加(OR: 1.75, 95% CI: 0.81-3.76),男性除外(OR: 2.49, 95% CI: 1.02-6.12)。

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基于潜在群体成员资格的 18,313 名个体的空腹血糖 (FPG) 轨迹

研究结果表明,在非糖尿病和糖尿病人群中,FPG的水平与骨质疏松症的不同风险相关。研究表明,FPG水平的控制对于预防骨质疏松症至关重要。通过控制FPG的水平,可以有效降低骨质质疏松症的风险。

因此,适当的FPG血糖水平是预防骨质疏松症的必要条件。这可以通过采取一系列措施来实现,包括合理的饮食控制、适当的体育锻炼、规律的药物治疗和良好的生活习惯。稳定的FPG水平有助于维持骨骼健康,减少骨质疏松症的风险,并提高生活质量。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2160844, encodeId=f6d221608449e, content=。7冫字学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Wed Oct 04 08:09:38 CST 2023, time=2023-10-04, status=1, ipAttribution=山东省), GetPortalCommentsPageByObjectIdResponse(id=2160842, encodeId=10342160842a8, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=仁术2023, createdTime=Wed Oct 04 07:59:01 CST 2023, time=2023-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2160838, encodeId=3650216083824, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b08e8469269, createdName=ms4000000512201075, createdTime=Wed Oct 04 07:46:15 CST 2023, time=2023-10-04, status=1, ipAttribution=吉林省), GetPortalCommentsPageByObjectIdResponse(id=2160831, encodeId=8850216083155, content=调查FPG轨迹与非糖尿病和糖尿病人群骨质疏松风险之间的关联。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Wed Oct 04 06:27:38 CST 2023, time=2023-10-04, status=1, ipAttribution=河北省)]
    2023-10-04 八骏奔腾 来自山东省

    。7冫字学习了

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2160844, encodeId=f6d221608449e, content=。7冫字学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Wed Oct 04 08:09:38 CST 2023, time=2023-10-04, status=1, ipAttribution=山东省), GetPortalCommentsPageByObjectIdResponse(id=2160842, encodeId=10342160842a8, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=仁术2023, createdTime=Wed Oct 04 07:59:01 CST 2023, time=2023-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2160838, encodeId=3650216083824, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b08e8469269, createdName=ms4000000512201075, createdTime=Wed Oct 04 07:46:15 CST 2023, time=2023-10-04, status=1, ipAttribution=吉林省), GetPortalCommentsPageByObjectIdResponse(id=2160831, encodeId=8850216083155, content=调查FPG轨迹与非糖尿病和糖尿病人群骨质疏松风险之间的关联。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Wed Oct 04 06:27:38 CST 2023, time=2023-10-04, status=1, ipAttribution=河北省)]
    2023-10-04 仁术2023

    不错,学习了。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2160844, encodeId=f6d221608449e, content=。7冫字学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Wed Oct 04 08:09:38 CST 2023, time=2023-10-04, status=1, ipAttribution=山东省), GetPortalCommentsPageByObjectIdResponse(id=2160842, encodeId=10342160842a8, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=仁术2023, createdTime=Wed Oct 04 07:59:01 CST 2023, time=2023-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2160838, encodeId=3650216083824, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b08e8469269, createdName=ms4000000512201075, createdTime=Wed Oct 04 07:46:15 CST 2023, time=2023-10-04, status=1, ipAttribution=吉林省), GetPortalCommentsPageByObjectIdResponse(id=2160831, encodeId=8850216083155, content=调查FPG轨迹与非糖尿病和糖尿病人群骨质疏松风险之间的关联。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Wed Oct 04 06:27:38 CST 2023, time=2023-10-04, status=1, ipAttribution=河北省)]
    2023-10-04 ms4000000512201075 来自吉林省

    不错,学习了。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2160844, encodeId=f6d221608449e, content=。7冫字学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnHtEgiaNiaUeanPblicnQPORicamAtCLvWmTKDxxWwF3J99R5MdjnGACh16icoScCeRrNQOibvvPqiaDrA/132, createdBy=83465314460, createdName=八骏奔腾, createdTime=Wed Oct 04 08:09:38 CST 2023, time=2023-10-04, status=1, ipAttribution=山东省), GetPortalCommentsPageByObjectIdResponse(id=2160842, encodeId=10342160842a8, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4dfa6526517, createdName=仁术2023, createdTime=Wed Oct 04 07:59:01 CST 2023, time=2023-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2160838, encodeId=3650216083824, content=不错,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b08e8469269, createdName=ms4000000512201075, createdTime=Wed Oct 04 07:46:15 CST 2023, time=2023-10-04, status=1, ipAttribution=吉林省), GetPortalCommentsPageByObjectIdResponse(id=2160831, encodeId=8850216083155, content=调查FPG轨迹与非糖尿病和糖尿病人群骨质疏松风险之间的关联。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d3d3015017, createdName=jshbyywk2008, createdTime=Wed Oct 04 06:27:38 CST 2023, time=2023-10-04, status=1, ipAttribution=河北省)]
    2023-10-04 jshbyywk2008 来自河北省

    调查FPG轨迹与非糖尿病和糖尿病人群骨质疏松风险之间的关联。

    0

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