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Crit Care Med:性别与重症脓毒症的结局相关么?

2017-08-19 MedSci MedSci原创

近期,一项发表在杂志Crit Care Med上的研究旨在确定性别与脓毒症危重患者的临床表现、结局和宿主反应之间的关系。此项研究为2011年1月至2014年1月在两所三级医院ICU进行的前瞻性观察性队列研究。受试人群为所有入院的脓毒症危重病人,共有1,815例入院(1,533例)。此项研究测量了能够反映脓毒病发病机制(1,205名)的19个血浆生物标志物,并通过全基因组血液基因表达谱(582名)评

近期,一项发表在杂志Crit Care Med上的研究旨在确定性别与脓毒症危重患者的临床表现、结局和宿主反应之间的关系。此项研究为2011年1月至2014年1月在两所三级医院ICU进行的前瞻性观察性队列研究。受试人群为所有入院的脓毒症危重病人,共有1,815例入院(1,533例)。此项研究测量了能够反映脓毒病发病机制(1,205名)的19个血浆生物标志物,并通过全基因组血液基因表达谱(582名)评估了ICU入院患者的宿主反应。此项研究结果显示:进入ICU的脓毒症患者更多的是男性(61.0%; p <0.0001 vs女性)。性别的基线特征没有差异。尿脓毒症在女性中更常见;心内膜炎和纵隔炎在男性中更常见。整个ICU停留期间疾病严重程度相似。ICU入院后1年的死亡率类似,性别与多变量分析中的90天死亡率无关。虽然血浆蛋白质组分析(包括全身炎症和细胞因子反应以及凝血酶活化)在性别之间大致相似,但女性患者的内皮细胞活化增强;但是55岁以上的患者出现没有这种差异。在男性和女性患者中,超过80%的白细胞血液基因表达反应相似。此项研究结果表明:入住ICU的男性和女性败血症患者的宿主反应和临床结

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    2017-09-03 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

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    2017-08-21 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

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    2017-08-19 半夏微凉

    学习了谢谢分享

    0

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