Hepatology：microRNA-155调节肝损伤的新机制！

2018-02-09 MedSci MedSci原创

有研究表明miR-155参与免疫和炎性疾病，并与肝纤维化和脂肪性肝炎相关。然而，涉及miR-155调控肝损伤的机制尚未完全明了。近期，一项发表在杂志Hepatology上的研究使用野生型（WT）、移植WT骨髓的miR-155 -/- 和miR-155 -/- 的小鼠中评估了miR-155在急性肝损伤中的作用。此外，在患有自身免疫性肝炎的患者的肝脏组织和外周血单核细胞（PBMC）中评估了miR-15

有研究表明miR-155参与免疫和炎性疾病，并与肝纤维化和脂肪性肝炎相关。然而，涉及miR-155调控肝损伤的机制尚未完全明了。

近期，一项发表在杂志Hepatology上的研究使用野生型（WT）、移植WT骨髓的miR-155 -/- 和miR-155 -/- 的小鼠中评估了miR-155在急性肝损伤中的作用。此外，在患有自身免疫性肝炎的患者的肝脏组织和外周血单核细胞（PBMC）中评估了miR-155的表达情况。

此项研究结果显示，Concanavalin A（ConA）而非对乙酰氨基酚（APAP）的处理增加了WT小鼠肝脏组织中miR-155的表达。与WT小鼠相比，ConA诱导了miR-155 -/- 小鼠中细胞死亡，肝转氨酶的增加和促炎细胞因子（Cxcl1,5,9,10,11，Ccl2,20和Icam1）的表达升高。重要的是，这些动物显示CD4 + CXCR3 +和Foxp3 +细胞募集显着降低，但在其他炎症细胞群中没有变化。

从机制上看，miR-155缺陷型Treg显示Ship1（miR-155的已知靶标）表达的增加。 Ship1在miR-155 -/- 小鼠中的抑制恢复了Foxp3的募集并降低肝细胞因子表达。通过促炎性细胞因子和细胞死亡蛋白表达评估，野生型小鼠的骨髓移植到miR-155 -/- 小鼠中部分地改变了ConA对miR-155 -/- 小鼠的作用。自身免疫性肝炎患者肝脏中miR-155表达显着增加，但PBMC中miR-155表达降低。

此项研究结果表明：在肝脏损伤期间，肝脏组织和循环炎性细胞中的miR-155表达发生改变，从而调节炎性细胞募集和肝损伤。这些结果表明维持miR-155在炎症细胞中的表达可能是调节肝损伤的潜在策略。

原始出处：
Blaya D, Aguilar-Bravo B, et al. Expression of microRNA-155 in inflammatory cells modulates liver injury. Hepatology. 2018 Feb 8. doi: 10.1002/hep.29833.

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2018-07-22 jiafufeng@yaho

#CRO#

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2018-03-05 xjy02

#Micro#

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2018-02-15 大爰

学习了谢谢分享!!

79 0
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createdName=半夏微凉, createdTime=Sat Feb 10 08:25:56 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
2018-02-13 1209e435m98(暂无昵称)

学习了.谢谢分享

98 0
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2018-02-11 12498bd5m16暂无昵称

#肝损伤#

67 0
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createdName=半夏微凉, createdTime=Sat Feb 10 08:25:56 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
2018-02-11 ms3046638856685384

#损伤#

61 0
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createdName=半夏微凉, createdTime=Sat Feb 10 08:25:56 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
2018-02-11 gwc384

#EPA#

67 0
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style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Feb 11 09:06:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286731, encodeId=64fe286e3174, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Feb 10 08:25:56 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
2018-02-11 zhouqu_8

#microRNA#

58 0
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authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sun Feb 11 09:06:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1427014, encodeId=f644142e014aa, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Sun Feb 11 09:06:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435709, encodeId=99a21435e0901, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Feb 11 09:06:00 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286731, encodeId=64fe286e3174, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Sat Feb 10 08:25:56 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
2018-02-10 半夏微凉

学习了谢谢分享

68 0

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