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Pain Med :长期使用阿片类药物不会增加阿尔茨海默氏症的风险

2017-10-24 MedSci MedSci原创

芬兰东部大学最近的一项研究显示,阿片类药物的使用与阿尔茨海默病风险增加无关。研究人员没有发现长期使用或累积剂量较高的风险。阿片类药物是治疗神经系统的强力镇痛药物。该研究发表在《Pain Medicine》杂志上,是迄今为止对这个话题进行的最广泛的研究。美国之前的一项研究报告说,高剂量的阿片类药物与痴呆风险增加之间存在关联,但芬兰的研究并没有证实这一发现。然而,一些不良反应与阿片类药物的使用有关,如


芬兰东部大学最近的一项研究显示,阿片类药物的使用与阿尔茨海默病风险增加无关。研究人员没有发现长期使用或累积剂量较高的风险。阿片类药物是治疗神经系统的强力镇痛药物。
该研究发表在《Pain Medicine》杂志上,是迄今为止对这个话题进行的最广泛的研究。美国之前的一项研究报告说,高剂量的阿片类药物与痴呆风险增加之间存在关联,但芬兰的研究并没有证实这一发现。

然而,一些不良反应与阿片类药物的使用有关,如嗜睡和警觉性降低,因此,阿片类药物的使用仅限于最严重的疼痛情况。阿片类药物的使用也可能导致成瘾或对疼痛缓解的耐受性。

对患有阿尔茨海默病的芬兰患者和未患该病的对照者进行阿片类药物的使用进行比较。这项研究是国内注册的MEDALZ研究的一部分,其中包括2005年至2011年在芬兰被诊断为阿尔茨海默氏症的70,718例患者,以及282,862名对照者。

原文出处:Heidi Taipale et al. Is Alzheimer's Disease Associated with Previous Opioid Use?, Pain Medicine (2017).

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createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Sun May 20 03:47:00 CST 2018, time=2018-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010149, encodeId=f3dc2010149b2, content=<a href='/topic/show?id=3ea49698234' target=_blank style='color:#2F92EE;'>#长期使用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96982, encryptionId=3ea49698234, topicName=长期使用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=365d170, createdName=chenwq08, createdTime=Fri Apr 20 13:47:00 CST 2018, time=2018-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1816812, encodeId=9d5b18168126e, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, 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encodeId=6bad130906e75, content=<a href='/topic/show?id=a0179e879ac' target=_blank style='color:#2F92EE;'>#阿片类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97879, encryptionId=a0179e879ac, topicName=阿片类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Thu Oct 26 12:47:00 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470189, encodeId=be2c14e01894a, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Thu Oct 26 12:47:00 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  5. 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encodeId=6bad130906e75, content=<a href='/topic/show?id=a0179e879ac' target=_blank style='color:#2F92EE;'>#阿片类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97879, encryptionId=a0179e879ac, topicName=阿片类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e12358, createdName=lhlxtx, createdTime=Thu Oct 26 12:47:00 CST 2017, time=2017-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470189, encodeId=be2c14e01894a, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Thu Oct 26 12:47:00 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Oct 25 08:14:55 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255704, encodeId=5d48255e045b, content=谢谢分享.很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Tue Oct 24 23:27:43 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
  6. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Oct 25 08:14:55 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255704, encodeId=5d48255e045b, content=谢谢分享.很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Tue Oct 24 23:27:43 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-26 lhlxtx
  7. 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  9. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Oct 25 08:14:55 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255704, encodeId=5d48255e045b, content=谢谢分享.很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Tue Oct 24 23:27:43 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-25 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  10. 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createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Oct 25 08:14:55 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255704, encodeId=5d48255e045b, content=谢谢分享.很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a6831717982, createdName=微分, createdTime=Tue Oct 24 23:27:43 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-24 微分

    谢谢分享.很好

    0

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专家指南推荐当风险超过获益时,应当减少或停止长期阿片类药物治疗(LTOT),但减剂量对患者结局影响的证据还没有被系统评价过。2017年8月,发表在《Ann Intern Med.》的一项系统评价调查了LTOT减剂量或停药后的患者结局。

美国阿片类药物危机频发 医生因开药过度面临审判

在美国,阿片类药物上瘾已成为全美健康问题。当前,开具过多危险止痛药的医生正面临法庭的审判。

七成疼痛患者未规范化镇痛治疗,阿片类药物用不用?

2017年中国癌症统计年报数据显示,中国癌症患者的数量不断攀升,癌症新发人数增加到459万,占世界的1/4。疼痛是肿瘤患者最常见的伴随性疾病,60%在接受抗肿瘤治疗的患者会出现疼痛,然而70%的疼痛患者未接受规范化的镇痛治疗。“作为目前已发现的镇痛作用最强、止痛疗效最确切的药物,阿片类药物是治疗癌痛的首选,这是世界范围内的共识,得到了美国国立综合癌症网络(NCCN)、欧洲临床肿瘤学会(ESMO)、

哪个病最痛?牙痛仅排第五位!别忍了,它能帮到你!

你以为牙疼是最疼的?NO!难产、癌症晚期最疼!近日,中国麻醉药品协会、蔚蓝丝带关爱癌痛患者协作组携手共同举办了“阿片类药物合理使用座谈会”。 蔚蓝丝带关爱癌痛患者特邀专家组成员,中国抗癌协会监事会监事,陆军总医院专家组成员刘端祺教授分享了一组数据:难产的疼痛指数到100,排所有疼痛的第一位,第二个就是癌症晚期,疼痛指数达到95。大家都得过病,牙病疼起来要命,在疼痛里才排第五。“如果从癌症来讲,食管

Arthritis Rheumatol:美国类风湿关节炎患者阿片类药物使用趋势变化

阿片类药物是迄今为止最有效的镇痛药物,但滥用已经是个极大的社会问题。阿片类药物处方最近受到了严格的审查。2017年9月,发表在《Arthritis Rheumatol.》的一项研究调查了美国类风湿关节炎患者阿片类药物使用趋势的变化。

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