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J Rheumatol:与巨细胞动脉炎复发和糖皮质激素依赖相关的因素

2019-08-27 xiangting MedSci原创

LVV是复发和GC依赖的独立预测因子。需要进一步的前瞻性研究来证实这些发现,并确定LVV患者是否需要不同的治疗方法。

这项研究旨在确定巨细胞动脉炎(GCA)患者复发和糖皮质激素(GC)依赖的特征及相关因素。

研究回顾性分析了326例连续性GCA患者,随访至少12个月。在多因素分析中确定了与复发和GC依赖相关的因素。

对326例患者(73%为女性)进行了62个月的随访(12-262)。随访期间,171例患者(52%)复发,其中113例患者(35%)发生GC依赖。复发患者较少有卒中史(p=0.01),并且成像时大血管血管炎(LVV)比无复发患者更常见(p=0.01)。最初几个月,复发和非复发患者的治疗策略没有差别。与无GC依赖性疾病的患者相比,GC依赖患者的卒中史更少见(p=0.004),并且成像时的LVV更常见(p=0.005)。在多因素分析中,LVV是复发(HR 1.49,95%CI 1.002-2.12; p=0.04)和GC依赖的独立预测因子(OR 2.19,95%CI 1.19-4.05;p=0.01)。与之相反,卒中是复发(HR 0.21,95%CI 0.03-0.68; p=0.005)和GC依赖性疾病的保护性因素(OR 0.10,95%CI 0.001-0.31; p=0.0005)。接受GC保留剂治疗的GC依赖患者的GC治疗时间短于没有使用保留剂的患者(p=0.008)。

在这项研究中,LVV是复发和GC依赖的独立预测因子。需要进一步的前瞻性研究来证实这些发现,并确定LVV患者是否需要不同的治疗方法。

原始出处:

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    2019-10-08 xsm927
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    2019-08-29 wwzzly
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    2019-08-28 qingfengqishi5

    学习了,学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1701265, encodeId=1cb71e012650c, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Thu May 14 11:39:00 CST 2020, time=2020-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683202, encodeId=3bc7168320218, content=<a href='/topic/show?id=60f03325e28' target=_blank style='color:#2F92EE;'>#动脉炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33257, encryptionId=60f03325e28, topicName=动脉炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d22a27947071, createdName=xsm927, createdTime=Tue Oct 08 18:39:00 CST 2019, time=2019-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502263, encodeId=cc1a15022639c, content=<a href='/topic/show?id=021d4821096' target=_blank style='color:#2F92EE;'>#巨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48210, encryptionId=021d4821096, topicName=巨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11759518880, createdName=wwzzly, createdTime=Thu Aug 29 10:39:00 CST 2019, time=2019-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600389, encodeId=7f1c1600389b2, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb1a18781011, createdName=bbwznl, createdTime=Thu Aug 29 10:39:00 CST 2019, time=2019-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371934, encodeId=3e4b3e193492, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Wed Aug 28 22:57:28 CST 2019, time=2019-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371930, encodeId=5fef3e19303d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Aug 28 22:45:04 CST 2019, time=2019-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371876, encodeId=db9d3e187647, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Tue Aug 27 20:33:28 CST 2019, time=2019-08-27, status=1, ipAttribution=)]
    2019-08-28 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2019-08-27 orangesking

    0

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