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Crit Care Med:ICU的危险信号!

2018-02-22 MedSci MedSci原创

无菌性和传染性危重疾病通常会导致血管痉挛性休克和强烈的全身炎症反应。先天免疫系统是对传染性和创伤性打击反应的中心。损伤相关的分子模式是从应激或濒死细胞释放的一些小分子。损伤相关的分子模式激活模式识别受体并协调先天免疫反应的前沿。近期,一项发表在杂志Crit Care Med上的综述介绍了损伤相关分子模式的概念以及它们如何激活全身炎症反应,特别是在创伤、神经系统损伤和感染中。此外,还探讨了在极端情况

无菌性和传染性危重疾病通常会导致血管痉挛性休克和强烈的全身炎症反应。先天免疫系统是对传染性和创伤性打击反应的中心。损伤相关的分子模式是从应激或濒死细胞释放的一些小分子。损伤相关的分子模式激活模式识别受体并协调先天免疫反应的前沿。

近期,一项发表在杂志Crit Care Med上的综述介绍了损伤相关分子模式的概念以及它们如何激活全身炎症反应,特别是在创伤、神经系统损伤和感染中。此外,还探讨了在极端情况下,损害相关的分子模式如何使多系统器官衰竭永久化。

此项研究综述了截至2017年8月的PubMed搜索获得基础和临床研究。包含的文章包括原创文章,评论文章和会议论文集。对科学、同行评审的数据进行了分析。包括并总结了由作者裁定的高质量临床前和临床研究。

模式识别受体响应损伤相关的分子模式,然后激活炎症通路。损伤相关的分子模式与前哨白细胞的募集和炎症级联的启动有关。损伤相关的分子模式与危重疾病的许多症状有关。临床前模型增加了他们如何介导远端器官功能障碍的见解。

综上所述,损伤相关的分子模式激活和释放是重症监护医生的一项重要研究。这将增加我们对先天免疫反应的阶段和状态的理解。早期的研究成果令人鼓舞。然而,只有更好地了解与损伤相关的分子模式激活和功能,才可能希望将损伤相关的分子模式作为未来的诊断和/或治疗模式。

原始出处:
Schenck EJ, Ma KC, et al. Danger Signals in the ICU. Crit Care Med. 2018 Feb 13. doi: 10.1097/CCM.0000000000003007.

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    2018-02-26 大爰

    学习了谢谢分享!!

    0

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    2018-02-24 大爰

    学习了谢谢分享!!

    0

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