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Lancet Infect Dis:英国猴痘病毒感染病例的人口统计学及临床特征

2022-07-06 MedSci原创 MedSci原创

在这项观察性分析中,我们考虑了在 2022 年 5 月 14 日至 5 月 25 日期间在英国伦敦的开放式性健康诊所就诊的 PCR 检测确诊猴痘病毒感染的患者。我们报告了住院人数和并发性传播感染 (S

背景
从历史上看,英国的人类猴痘病毒病例仅限于从西非输入的感染病例。目前,英国和其他几个国家报告说,在性健康诊所就诊的人中猴痘病例迅速增加,与流行地区没有明显的流行病学联系。我们描述了在性健康中心就诊的被​​诊断患有人类猴痘病毒的患者的人口统计学和临床​​特征。

方法
在这项观察性分析中,我们考虑了在 2022 年 5 月 14 日至 5 月 25 日期间在英国伦敦的开放式性健康诊所就诊的 PCR 检测确诊猴痘病毒感染的患者。我们报告了住院人数和并发性传播感染 (STI) 比例,并描述我们在疫情爆发的前 2 周内的当地反应。

发现
猴痘病毒感染在 54 人中得到证实,他们都被认定为男男性行为者 (MSM),中位年龄为 41 岁 (IQR 34-45)。 54 人中有 38 人(70%)是白人,26 人(48%)出生在英国,13 人(24%)感染 HIV。 54 人中有 36 人(67%)报告疲劳或嗜睡,31 人(57%)报告发烧,10 人(18%)没有前驱症状。所有患者均出现皮肤损伤,其中 51 名 (94%) 为肛门生殖器。 54 人中有 37 人 (89%) 有超过一个解剖部位的皮肤病变,4 人 (7%) 有口咽病变。 54 人中有 30 人(55%)有淋巴结病。四分之一的患者同时患有 STI。 54 人中有 5 人 (9%) 需要住院,主要是由于疼痛或需要抗生素干预或镇痛的局部细菌性蜂窝织炎。我们没有记录到致命的结果。

解释
目前在英国的 MSM 中观察到本土社区猴痘病毒传播。我们发现了高比例的伴随性传播感染和频繁的肛门生殖器症状,这表明在性活动期间皮肤与皮肤或粘膜密切接触期间通过局部接种进行传播。需要额外的资源来支持性健康和其他专业服务来管理这种情况。需要审查病例定义并更好地了解病毒传播途径,以制定感染控制政策、教育和预防策略以及接触者追踪。

原始出处:

Girometti N, Byrne R, Bracchi M, Heskin J, McOwan A, Tittle V, Gedela K, Scott C, Patel S, Gohil J, Nugent D, Suchak T, Dickinson M, Feeney M, Mora-Peris B, Stegmann K, Plaha K, Davies G, Moore LSP, Mughal N, Asboe D, Boffito M, Jones R, Whitlock G.Demographic and clinical characteristics of confirmed human monkeypox virus cases in individuals attending a sexual health centre in London, UK: an observational analysis.Lancet Infect Dis. 2022 Jul 1:S1473-3099(22)00411-X. doi: 10.1016/S1473-3099(22)00411-X

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    2022-10-01 howi
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    2023-04-21 cmj8wellington
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    2022-07-08 siiner
  5. [GetPortalCommentsPageByObjectIdResponse(id=1831604, encodeId=0cb7183160401, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Oct 01 18:41:48 CST 2022, time=2022-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013919, encodeId=9947201391932, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Apr 21 18:41:48 CST 2023, time=2023-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843008, encodeId=03c9184300865, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Thu May 04 20:41:48 CST 2023, time=2023-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442323, encodeId=ae171442323a1, content=<a href='/topic/show?id=4989e8938c9' target=_blank style='color:#2F92EE;'>#统计学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78938, encryptionId=4989e8938c9, topicName=统计学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df8a4916199, createdName=siiner, createdTime=Fri Jul 08 00:41:48 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604364, encodeId=36ce1604364a3, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Fri Jul 08 00:41:48 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230915, encodeId=3e1a123091535, content=谁也无法预测人在吃饱饭后会干出什么样的事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Wed Jul 06 14:21:00 CST 2022, time=2022-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244041, encodeId=e5b01244041b1, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Wed Jul 06 12:41:48 CST 2022, time=2022-07-06, status=1, ipAttribution=)]
    2022-07-08 xugc
  6. [GetPortalCommentsPageByObjectIdResponse(id=1831604, encodeId=0cb7183160401, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Oct 01 18:41:48 CST 2022, time=2022-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013919, encodeId=9947201391932, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Apr 21 18:41:48 CST 2023, time=2023-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843008, encodeId=03c9184300865, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Thu May 04 20:41:48 CST 2023, time=2023-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442323, encodeId=ae171442323a1, content=<a href='/topic/show?id=4989e8938c9' target=_blank style='color:#2F92EE;'>#统计学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78938, encryptionId=4989e8938c9, topicName=统计学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df8a4916199, createdName=siiner, createdTime=Fri Jul 08 00:41:48 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604364, encodeId=36ce1604364a3, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Fri Jul 08 00:41:48 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230915, encodeId=3e1a123091535, content=谁也无法预测人在吃饱饭后会干出什么样的事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Wed Jul 06 14:21:00 CST 2022, time=2022-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244041, encodeId=e5b01244041b1, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Wed Jul 06 12:41:48 CST 2022, time=2022-07-06, status=1, ipAttribution=)]
    2022-07-06 weigq

    谁也无法预测人在吃饱饭后会干出什么样的事情!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1831604, encodeId=0cb7183160401, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Oct 01 18:41:48 CST 2022, time=2022-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013919, encodeId=9947201391932, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Fri Apr 21 18:41:48 CST 2023, time=2023-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843008, encodeId=03c9184300865, content=<a href='/topic/show?id=112222886b8' target=_blank style='color:#2F92EE;'>#临床特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22886, encryptionId=112222886b8, topicName=临床特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=yeye5224612, createdTime=Thu May 04 20:41:48 CST 2023, time=2023-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442323, encodeId=ae171442323a1, content=<a href='/topic/show?id=4989e8938c9' target=_blank style='color:#2F92EE;'>#统计学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78938, encryptionId=4989e8938c9, topicName=统计学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df8a4916199, createdName=siiner, createdTime=Fri Jul 08 00:41:48 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604364, encodeId=36ce1604364a3, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Fri Jul 08 00:41:48 CST 2022, time=2022-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1230915, encodeId=3e1a123091535, content=谁也无法预测人在吃饱饭后会干出什么样的事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210703/9c448fe1b3b54fd7bc9477662f4861bb/4bdadad22bfd46f2921aabb4c40265d3.jpg, createdBy=a8d81938466, createdName=weigq, createdTime=Wed Jul 06 14:21:00 CST 2022, time=2022-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1244041, encodeId=e5b01244041b1, content=lancet上果然牛,感谢梅斯更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Wed Jul 06 12:41:48 CST 2022, time=2022-07-06, status=1, ipAttribution=)]
    2022-07-06 younei

    lancet上果然牛,感谢梅斯更新及时

    0

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