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Nature:澳研究者发现可让癌细胞“冬眠”的免疫细胞

2019-01-08 佚名 中国科学报

癌细胞难以被彻底消灭,那么是否可以退而求其次,通过使它们进入永久“冬眠”状态来拯救病人呢?澳大利亚研究人员日前发现了一种有这样功能的免疫细胞,有望为治疗癌症提供新思路。

癌细胞难以被彻底消灭,那么是否可以退而求其次,通过使它们进入永久“冬眠”状态来拯救病人呢?澳大利亚研究人员日前发现了一种有这样功能的免疫细胞,有望为治疗癌症提供新思路。

澳大利亚泰莱松儿童研究所等机构研究人员在英国《自然》杂志上报告说,他们发现一种名为TRM细胞的免疫细胞能让黑色素瘤细胞处于“冬眠”状态。黑色素瘤是由皮肤上的色素组织发生病变引起的一种癌症,目前尚无有效治疗药物。

这项研究发现,在有TRM细胞存在的时候,黑色素瘤细胞的增长受到抑制,就像“冬眠”了一样。但如果去除TRM细胞,则黑色素瘤细胞会快速增长,导致癌症症状加重。

研究人员说,此前科学界已经知道恶性肿瘤细胞在引发危及生命的症状之前,可能在人体内“和平潜伏”几年甚至几十年的时间,但对相关机制一直缺乏深入了解。本次发现的TRM细胞可能对其他类型癌细胞也有效,这有助于开发治疗癌症的新方法。

原始出处:

Simone L. Park, Anthony Buzzai, Jai Rautela, et.al. Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin. Nature 31 December 2018

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    2019-11-02 stfoxst
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    2019-11-16 liye789132251
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    2019-01-10 yxch36
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    2019-01-09 kafei

    学习了谢谢

    0

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    2019-01-08 医者仁心5538

    学习了

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