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Heart:风湿性心脏病患者卒中的发生率和预测因素

2021-01-22 MedSci原创 MedSci原创

在这个大型的RHD患者队列中,5.2%的患者发生卒中,这可由年龄、房颤和既往卒中所预测。房颤对卒中风险评估的影响受到死亡作为竞争风险的影响。

缺血性卒中是风湿性心脏病(RHD)患者的严重并发症,可能导致永久性残疾和死亡。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,该研究旨在评估RHD患者卒中的发生率和预测因素。

研究人员选择了经临床和超声心动图诊断为RHD的患者。在受试者入组时进行了结构化的临床和神经学评估,以确定卒中的病因和分类。

该研究的主要终点是缺血性脑血管事件,包括致命或非致命性卒中。研究人员对卒中风险进行了评估,并考虑了竞争风险。

该研究共纳入了515例患者,其中女性438例(85%),年龄为46±12岁。最常见的瓣膜病变是混合二尖瓣病变(80%)。入组时,92例患者(18%)既往有过卒中,最常见的是前循环梗死(72%)。在平均3.9年的随访中,27名患者(5.2%)发生脑卒中,总发生率为每100名患者每年1.47人。Cox模型预测卒中的因素包括既往卒中(校正后HR为5.395, 95%CI为2.272-12.811)、年龄(HR为1.591, 95%CI为1.116-2.269)和基线时房颤(HR为2.945, 95%CI为1.083-8.007)。通过将死亡作为竞争风险,AF对卒中风险的影响有所减弱(HR为2.287, 95%CI为0.962-5.441)。

由此可见,在这个大型的RHD患者队列中,5.2%的患者发生卒中,这可由年龄、房颤和既往卒中所预测。房颤对卒中风险评估的影响受到死亡作为竞争风险的影响。

原始出处:

Marcelle Vasconcelos.et al.Incidence and predictors of stroke in patients with rheumatic heart disease.heart.2021.http://dx.doi.org/10.1136/heartjnl-2020-318054

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79875454878, createdName=tracy, createdTime=Sat Jan 23 06:19:53 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026753, encodeId=b71a1026e539e, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jan 22 10:45:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918945, encodeId=9a06918945d3, content=学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a7a5402211, createdName=ms2000002125907968, createdTime=Fri Jan 22 10:39:27 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918915, encodeId=2830918915b9, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210122/ce2afd37c8ee477585364ea0ace651a7/acf7a88cfd184c1f9a24a04925048b4f.jpg, createdBy=078c5454872, createdName=ms7000000709511634, createdTime=Fri Jan 22 08:39:03 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918909, encodeId=5b009189094d, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jan 22 07:59:16 CST 2021, time=2021-01-22, status=1, ipAttribution=)]
    2021-01-23 zhaojie88
  5. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79875454878, createdName=tracy, createdTime=Sat Jan 23 06:19:53 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026753, encodeId=b71a1026e539e, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jan 22 10:45:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918945, encodeId=9a06918945d3, content=学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a7a5402211, createdName=ms2000002125907968, createdTime=Fri Jan 22 10:39:27 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918915, encodeId=2830918915b9, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210122/ce2afd37c8ee477585364ea0ace651a7/acf7a88cfd184c1f9a24a04925048b4f.jpg, createdBy=078c5454872, createdName=ms7000000709511634, createdTime=Fri Jan 22 08:39:03 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918909, encodeId=5b009189094d, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jan 22 07:59:16 CST 2021, time=2021-01-22, status=1, ipAttribution=)]
    2021-01-23 slcumt
  6. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79875454878, createdName=tracy, createdTime=Sat Jan 23 06:19:53 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026753, encodeId=b71a1026e539e, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jan 22 10:45:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918945, encodeId=9a06918945d3, content=学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a7a5402211, createdName=ms2000002125907968, createdTime=Fri Jan 22 10:39:27 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918915, encodeId=2830918915b9, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210122/ce2afd37c8ee477585364ea0ace651a7/acf7a88cfd184c1f9a24a04925048b4f.jpg, createdBy=078c5454872, createdName=ms7000000709511634, createdTime=Fri Jan 22 08:39:03 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918909, encodeId=5b009189094d, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jan 22 07:59:16 CST 2021, time=2021-01-22, status=1, ipAttribution=)]
    2021-01-23 tracy

    学习

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79875454878, createdName=tracy, createdTime=Sat Jan 23 06:19:53 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026753, encodeId=b71a1026e539e, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jan 22 10:45:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918945, encodeId=9a06918945d3, content=学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a7a5402211, createdName=ms2000002125907968, createdTime=Fri Jan 22 10:39:27 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918915, encodeId=2830918915b9, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210122/ce2afd37c8ee477585364ea0ace651a7/acf7a88cfd184c1f9a24a04925048b4f.jpg, createdBy=078c5454872, createdName=ms7000000709511634, createdTime=Fri Jan 22 08:39:03 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918909, encodeId=5b009189094d, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jan 22 07:59:16 CST 2021, time=2021-01-22, status=1, ipAttribution=)]
    2021-01-22 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79875454878, createdName=tracy, createdTime=Sat Jan 23 06:19:53 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026753, encodeId=b71a1026e539e, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jan 22 10:45:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918945, encodeId=9a06918945d3, content=学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a7a5402211, createdName=ms2000002125907968, createdTime=Fri Jan 22 10:39:27 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918915, encodeId=2830918915b9, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210122/ce2afd37c8ee477585364ea0ace651a7/acf7a88cfd184c1f9a24a04925048b4f.jpg, createdBy=078c5454872, createdName=ms7000000709511634, createdTime=Fri Jan 22 08:39:03 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918909, encodeId=5b009189094d, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jan 22 07:59:16 CST 2021, time=2021-01-22, status=1, ipAttribution=)]
    2021-01-22 ms2000002125907968

    学习!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1826662, encodeId=d8f01826662a8, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sat May 15 23:45:17 CST 2021, time=2021-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264349, encodeId=8a1e1264349dc, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79875454878, createdName=tracy, createdTime=Sat Jan 23 06:19:53 CST 2021, time=2021-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026753, encodeId=b71a1026e539e, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Fri Jan 22 10:45:17 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918945, encodeId=9a06918945d3, content=学习!, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a7a5402211, createdName=ms2000002125907968, createdTime=Fri Jan 22 10:39:27 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918915, encodeId=2830918915b9, content=涨知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210122/ce2afd37c8ee477585364ea0ace651a7/acf7a88cfd184c1f9a24a04925048b4f.jpg, createdBy=078c5454872, createdName=ms7000000709511634, createdTime=Fri Jan 22 08:39:03 CST 2021, time=2021-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918909, encodeId=5b009189094d, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Fri Jan 22 07:59:16 CST 2021, time=2021-01-22, status=1, ipAttribution=)]
    2021-01-22 ms7000000709511634

    涨知识了

    0

  10. 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    2021-01-22 医鸣惊人

    认真学习了

    0

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