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Dent Mater J:一种全新改良根管封闭剂的物理和生物学特性

2019-11-12 lishiting MedSci原创

根管治疗的关键是消除微生物感染、严密充填根管系统和减少对尖周组织的刺激。然而,由于材料的缺陷,现代根管封闭剂很难满足所有的条件。在此,作者研发了一种全新的根管充填封闭剂(MZOE),它是将氧化锌丁香油酚(ZOE)与聚六亚甲基胍(PHMG)相结合,并且PHMG的浓度为0.8, 1.0, 1.2和1.4%。

根管治疗的关键是消除微生物感染、严密充填根管系统和减少对尖周组织的刺激。然而,由于材料的缺陷,现代根管封闭剂很难满足所有的条件。在此,作者研发了一种全新的根管充填封闭剂(MZOE),它是将氧化锌丁香油酚(ZOE)与聚六亚甲基胍(PHMG)相结合,并且PHMG的浓度为0.8, 1.0, 1.2和1.4%。

研究测试了它的物理特性、抗粪肠球菌和白色念珠菌等的活性和对人牙周膜成纤维细胞的毒性(HPDLFs)。结果显示,MZOE的特性符合ISO 6876:2001的标准,并且它的抗菌活性明显强于ZOE (p<0.05),HPDLFs的RGR测试结果在1到24%之间,属于中等强度的毒性。结果表明,MZOE具有良好的物理特性、较高的抗菌活性以及适中的细胞毒性。

原始出处:

Jia M, Nai Z, et al. Physical and biological properties of a novel root canal sealer modified by polyhexamethylene guanidine. Dent Mater J. 2019 Nov 6. doi: 10.4012/dmj.2018-154.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2061240, encodeId=38f9206124099, content=<a href='/topic/show?id=5bd4622567b' target=_blank style='color:#2F92EE;'>#根管封闭剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62256, encryptionId=5bd4622567b, topicName=根管封闭剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sat Oct 24 05:43:00 CST 2020, time=2020-10-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=375410, encodeId=eb913e54102f, content=非常受益,很好的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7b005228115, createdName=14794e5bm67(暂无昵称), createdTime=Sat Nov 16 19:24:17 CST 2019, time=2019-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443061, encodeId=7c5a144306125, content=<a href='/topic/show?id=674546e8323' target=_blank style='color:#2F92EE;'>#封闭剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46783, encryptionId=674546e8323, topicName=封闭剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b88a5021004, createdName=12498dd9m12暂无昵称, createdTime=Thu Nov 14 11:43:00 CST 2019, time=2019-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1522986, encodeId=0a8515229861c, content=<a href='/topic/show?id=c72462241ff' target=_blank style='color:#2F92EE;'>#根管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62241, encryptionId=c72462241ff, topicName=根管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba5e11492705, createdName=zhaozhouchifen, createdTime=Thu Nov 14 11:43:00 CST 2019, time=2019-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1617907, encodeId=e055161e90716, content=<a href='/topic/show?id=e88f6930185' target=_blank style='color:#2F92EE;'>#生物学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69301, encryptionId=e88f6930185, topicName=生物学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e44019811593, createdName=12498c32m74暂无昵称, createdTime=Thu Nov 14 11:43:00 CST 2019, time=2019-11-14, status=1, ipAttribution=)]
    2019-11-16 14794e5bm67(暂无昵称)

    非常受益,很好的研究

    0

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