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Nat Commun:10个军事和平民队列中PTSD的表观基因组元分析

2020-11-25 haibei MedSci原创

创伤后应激障碍(PTSD)的特点是重新体验、回避和过度狂热的症状,可以对情绪和生理健康产生负面影响。虽然不是每个经历过创伤的人都会发展成创伤后应激障碍,但那些经历过创伤的人往往会出现严重的致残症状。

创伤后应激障碍(PTSD)的特点是重新体验、回避和过度狂热的症状,可以对情绪和生理健康产生负面影响。虽然不是每个经历过创伤的人都会发展成创伤后应激障碍,但那些经历过创伤的人往往会出现严重的致残症状。研究表明,遗传和环境因素都会导致患创伤后应激障碍的风险。

表观遗传学差异可能有助于区分PTSD病例和创伤暴露对照组。在此,研究人员描述了迄今为止最大的PTSD DNA甲基化荟萃分析的结果。该研究包含了10个军队和平民队列,囊括了来自1,896个PTSD病例和创伤暴露对照的血源DNA甲基化数据。
经多重比较调整后,芳基烃受体抑制因子(AHRR)内的4个CpG位点与PTSD相关,PTSD病例的DNA甲基化程度相对于对照组较低。

虽然已知AHRR甲基化与吸烟相关,但AHRR与PTSD的关联在非吸烟者中最为明显,说明该结果与吸烟状态无关。
代谢组学数据的评估显示,AHRR甲基化与犬尿氨酸水平相关,而犬尿氨酸水平在PTSD受试者中较低。
该研究支持PTSD患者中的表观遗传学差异,并提示犬尿氨酸的降低是导致PTSD免疫失调的一个因素。

原始出处:
Alicia K. Smith et al. Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR. NATURE COMMUNICATIONS 2020.

 

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    2021-09-09 仁心济世
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    2021-08-09 liuli5079
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ipAttribution=)]
    2020-11-26 陈小凤

    0

  7. 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    2020-11-25 Psycho.Dr Du

    犬尿氨酸通路跟多种情绪失调密切相关,值得进一步研究#PTSD#

    0

  8. 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ipAttribution=)]
    2020-11-25 神盾医疗局局长Jack

    疑难问题

    0

  9. 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encodeId=61c99025951f, content=学, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/9iaAb4Jw2bbQql9icNGa5FjbmPicfSE7biaQIwz1AApCvib4HUmz3W6DibibX6BAgp4atWt9Qkox88aPJQY6GkvckxdfQ/132, createdBy=448e5312462, createdName=陈小凤, createdTime=Thu Nov 26 21:04:09 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902076, encodeId=43cf9020e69f, content=犬尿氨酸通路跟多种情绪失调密切相关,值得进一步研究<a href='/topic/show?id=255b1486e0a' target=_blank style='color:#2F92EE;'>#PTSD#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14867, encryptionId=255b1486e0a, topicName=PTSD)], attachment=null, authenticateStatus=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14867, encryptionId=255b1486e0a, topicName=PTSD)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Wed Nov 25 09:29:37 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902034, encodeId=b0bd90203443, content=原因应该不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Wed Nov 25 08:01:30 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
    2020-11-25 Sunny orchard

    犬尿氨酸是色氨酸代谢产物,后者也是人体中重要的神经递质——5-羟色胺的前体,相关因子相互影响可能是是导致#PTSD#免疫失调的一个因素。

    0

  10. 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createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Thu Sep 09 11:50:06 CST 2021, time=2021-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2087832, encodeId=b1fd208e83225, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Mon Aug 09 01:50:06 CST 2021, time=2021-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1905853, encodeId=87fe190585367, content=<a href='/topic/show?id=8f2f28546b3' target=_blank style='color:#2F92EE;'>#元分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28546, encryptionId=8f2f28546b3, topicName=元分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=jiangjun073, createdTime=Tue Aug 31 02:50:06 CST 2021, time=2021-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041026, encodeId=88df204102661, content=<a href='/topic/show?id=b88990244be' target=_blank style='color:#2F92EE;'>#表观基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90244, encryptionId=b88990244be, topicName=表观基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Nov 02 10:50:06 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902595, encodeId=61c99025951f, content=学, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/9iaAb4Jw2bbQql9icNGa5FjbmPicfSE7biaQIwz1AApCvib4HUmz3W6DibibX6BAgp4atWt9Qkox88aPJQY6GkvckxdfQ/132, createdBy=448e5312462, createdName=陈小凤, createdTime=Thu Nov 26 21:04:09 CST 2020, time=2020-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902076, encodeId=43cf9020e69f, content=犬尿氨酸通路跟多种情绪失调密切相关,值得进一步研究<a href='/topic/show?id=255b1486e0a' target=_blank style='color:#2F92EE;'>#PTSD#</a> , beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14867, encryptionId=255b1486e0a, topicName=PTSD)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Wed Nov 25 09:42:34 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902069, encodeId=4496902069bf, content=疑难问题, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Wed Nov 25 09:32:58 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902065, encodeId=25d990206502, content=犬尿氨酸是色氨酸代谢产物,后者也是人体中重要的神经递质——5-羟色胺的前体,相关因子相互影响可能是是导致<a href='/topic/show?id=255b1486e0a' target=_blank style='color:#2F92EE;'>#PTSD#</a>免疫失调的一个因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14867, encryptionId=255b1486e0a, topicName=PTSD)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200901/629d1ce7d6f64d17a642c37c90dea72c/202f9333a3ea4b23a9b07ede3364e86b.jpg, createdBy=1a335163906, createdName=Sunny orchard, createdTime=Wed Nov 25 09:29:37 CST 2020, time=2020-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=902034, encodeId=b0bd90203443, content=原因应该不同, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200914/f1df8506d5cb4909bac2efc340b6c1fe/dcc6dd2dbec44613838b555fbe723804.jpg, createdBy=686b1371609, createdName=liyu7822, createdTime=Wed Nov 25 08:01:30 CST 2020, time=2020-11-25, status=1, ipAttribution=)]
    2020-11-25 liyu7822

    原因应该不同

    0

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