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npj Digital Medicine:心情不好?可能是没睡好!

2021-03-06 MedSci原创 MedSci原创

睡眠对于人类健康的重要性不言而喻。据最新数据显示,我国有超3亿人存在睡眠障碍,而有人睡够8小时,却还是昏昏沉沉?多项研究表明,长期熬夜和睡眠不足的人对机体造成不可挽回的伤害。

睡眠对于人类健康的重要性不言而喻。据最新数据显示,我国有超3亿人存在睡眠障碍,而有人睡够8小时,却还是昏昏沉沉?多项研究表明,长期熬夜和睡眠不足的人对机体造成不可挽回的伤害。

近日,发表在npj Digital Medicine 杂志的一项研究显示,长期睡眠不规律可能会增加抑郁风险。每天睡眠时间减少,就寝时间延迟,更早的唤醒时间以及总睡眠时间和唤醒时间变化较大对第二天的情绪都有很大的影响。

在这项研究中,研究人员对2115名实习医师进行为期1年的不规律和情绪之间监测,其中56%的是女性,年龄在27.5±2.4岁。这些实习医师都经历了漫长且紧张的工作日和每天24小时都要轮换时间表,因此,实习医师可以作为一种预期模型,以更充分地了解更广泛的了解睡眠变异性与情绪之间的关系。参与者被要求在手腕上带上智能手表,以便收集睡眠和其他活动数据,并要求报告日常情绪并每季度进行一次抑郁症测试。

结果显示,睡眠时间波动较大的参与者抑郁症评分表得分更高,每天的情绪等级更低。那些经常熬夜或睡眠时间最少的参与者,在抑郁症状上的得分较高,日常情绪上的得分较低。

为了提供更清晰的数据,研究人员对抑郁和非抑郁参与者的客观睡眠指标进行了二次分析,1757名非抑郁参与者相比,抑郁参与者的睡眠监测数据的平均值均无显著差异24小时TST平均值:6.31 h vs.6.40 ht  = -1.77p  = 0.078;就寝时间的中位数:晚上11:09与晚上1105t  = 1.29p  = 0.20;唤醒时间中位数:上午6:34与上午633t  = 0.24p = 0.81),但均较大的变异性24小时TST SD1.29 h vs. 1.25 ht  = 2.32p  = 0.021;就寝时间SD3.70 h vs. 3.56 ht  = 2.61p   0.0094;唤醒时间SD3.43h3.29ht   3.02p   0.0027)。Bonferroni校正后,抑郁者和非抑郁者的唤醒时间中位数仍存在显着差异(显着性水平= 0.05 / 6 = 0.008)。

综上,不规律的睡眠可能会导致情绪低落和沮丧。然而,该研究所纳入的人群是相对年轻的人群(平均年龄为27岁,拥有大学和医学学位)不能代表更广泛的人群。未来,需要扩大人群研究范围,以更好额了解有关睡眠时间表变化对情绪的影响。

原始出处

Yu FangDaniel B. ForgerElena FrankSrijan Sen & Cathy Goldstein .Day-to-day variability in sleep parameters and depression risk: a prospective cohort study of training physicians.npj Digital MedicineDOI: 10.1038/s41746-021-00400-z

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    2022-01-26 kalseyzl
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    2021-06-19 venlin
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    2021-11-09 湘雅科教

    已拜读,受益匪浅。

    0

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    2021-09-04 jeanqiuqiu
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    2021-03-18 j3x

    学到了

    0

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    2021-03-06 jyzxjiangqin

    好文章!

    0

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微粉化的孕酮改善了各种睡眠结局指标,尤其是在绝经后妇女的研究中。进一步的研究可以在较大的人群中使用多导睡眠图或经过验证的调查表来评估微粉化的孕酮单药的疗效。

Science Advances:没睡好觉,也是月亮惹的祸?人类睡眠与月球周期

昨天的研究探讨了月球周期对女性月经的影响。虽然该研究还不能证明因果关系,但其中一些特征支持了月球周期与女性月经周期之间存在因果关系的合理性。

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