Am J Pathol：新研究为脓毒症的治疗奠定了基础

2016-04-12 MedSci MedSci原创

发表于American Journal of Pathology的一项新的研究揭示了对抗脓毒症的基础——SHARPIN，一种参与炎症调节的蛋白。

发表于American Journal of Pathology的一项新的研究揭示了对抗脓毒症的基础——SHARPIN，一种参与炎症调节的蛋白。

脓毒症是一种严重的感染并发症，且部分原因是由于缺乏有效的治疗，使得脓毒症成为导致世界上死亡及危重疾病发生的主要原因之一。而发表于American Journal of Pathology的一份研究报告提供来自小鼠和人类研究的证据，该研究表明，SHARPIN，一种参与炎症调节的蛋白，具有抗感染作用。这些研究发现可能会刺激新的败血症治疗方法的发展。

来自法兰克福大学药理及毒理学学院的药理学教授Liliana Schaefer解释道，“已知脓毒症可增强半胱天冬酶1的活性，并可促炎性白细胞介素1β和18的异常表达。SHARPIN可与半胱天冬酶1结合并抑制其活化。该研究表明，半胱天冬酶1 /SHARPIN相互作用或是对抗脓毒症的关键靶点，而且SHARPIN或许还参与了其他的炎症反应。”

研究人员发现，脓毒症小鼠缺乏SHARPIN可导致白细胞介素1β和18的水平升高以及半胱天冬酶1的活性增强，并会缩短小鼠的生存期。而给予小鼠半胱天冬酶1的抑制剂后，则可降低白细胞介素1β和18水平，减少脾细胞的死亡，延长小鼠的生存期。

研究人员还首次报道了这种机制可能与人类脓毒症有关。“我们发现脓毒症患者SHARPIN水平的降低可增强血液中单核细胞中的半胱天冬酶1的活性，并提高血浆中白细胞介素1β和18的水平，” Schaefer博士说道，“我们的研究结果表明，使用半胱天冬酶1抑制剂或可有益于SHARPIN水平较低的脓毒症患者，而且此疗法可能比其他抗炎疗法更有效。”

最近由重症医学协会和欧洲重症监护医学协会（JAMA 2016；315:801）工作小组召开的会议定义脓毒症为“由于宿主对感染失调所致的一种危及生命的器官功能失调的综合征。”脓毒性休克是脓毒症的一种，包括潜在的循环和细胞代谢异常，严重时可大大增加死亡的发生风险。脓毒症的症状包括体温变化，心跳加速，呼吸急促。其他症状包括尿量减少，精神状态改变，呼吸困难，腹痛以及血小板计数低。

原始出处：

Novel research lays the groundwork for new therapies against sepsis. MNT, Monday 11 April 2016.

Madalina-Viviana Nastase , Jinyang Zeng-Brouwers ,et al., An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis . American Journal of Pathology. March 08, 2016.

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2016-12-28 wolixiang2012

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2016-08-18 doctorJiangchao

继续学习

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2016-08-18 doctorJiangchao

继续关注

75 0
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2016-05-09 jaysppr

值得好好深读

43 0
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2016-05-09 jaysppr

值得深究！

187 0
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2016-05-09 jaysppr

不错的文章

183 0
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2016-09-10 yb6560

#Pathol#

85 0
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2016-04-14 李继凯

高大上的文章

105 0
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2016-04-14 李继凯

值得学习

120 0
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2016-04-13 xiaotaiyang1

期待科技的进步

144 0

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Am J Pathol：新研究为脓毒症的治疗奠定了基础

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