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Am J Clin Pathol:幽门螺杆菌治疗对慢性自发性荨麻疹患者结局的影响

2021-07-25 MedSci原创 MedSci原创

幽门螺杆菌与慢性自发性荨麻疹(CSU)之间的关系存在争议。近日,研究人员通过聚合酶链反应(PCR)直接诊断CSU患者的胃组织中的幽门螺杆菌,并研究幽门螺杆菌根除疗法与CSU缓解之间的关系,结果已发表于

幽门螺杆菌与慢性自发性荨麻疹(CSU)之间的关系存在争议。近日,研究人员通过聚合酶链反应(PCR)直接诊断CSU患者的胃组织中的幽门螺杆菌,并研究幽门螺杆菌根除疗法与CSU缓解之间的关系,结果已发表于Am J Clin Pathol。

在72名CSU患者中,有27名胃活检标本的幽门螺杆菌粪便抗原和PCR均为阳性,随机接受抗幽门螺杆菌或安慰剂治疗。

 

结果显示,幽门螺杆菌患者的血红蛋白浓度明显较低,并伴有小细胞低色素性贫血,消化不良症状的发生率明显较高。与安慰剂组相比,所有接受幽门螺杆菌治疗的患者(除两人外)在治疗2周后,荨麻疹的瘙痒和红斑有明显改善(P < .001)。治疗反应率为85.7%(12名患者;95%置信区间,64.3%-100.0%)。未能根除幽门螺杆菌的两名患者的幽门螺杆菌菌株对阿莫西林有耐药性。

综上,该研究发现CSU与胃组织中存在幽门螺杆菌感染之间存在关联。这是否为一种因果关系仍有待发现,但幽门螺杆菌的治疗可以明显改善CSU的症状。

 

原始出处:

 

Mohammed Elhendawy, et al., Positive Effect of Helicobacter pylori Treatment on Outcome of Patients With Chronic Spontaneous Urticaria. Am J Clin Pathol. 2021 Feb 11;155(3):405-411. doi: 10.1093/ajcp/aqaa134.

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    2024-01-07 zs-wwy 来自广东省

    学习了,受益,也试试杀菌

    0

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    2022-04-28 kcb069
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    2021-10-21 yb6560
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encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378796, encodeId=d7a613e87963b, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480042, encodeId=7c9c14800424c, content=<a href='/topic/show?id=f9e0530e169' target=_blank style='color:#2F92EE;'>#患者结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53071, encryptionId=f9e0530e169, topicName=患者结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=faa67597457, createdName=ms5906905816781247, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530633, encodeId=a98915306337c, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002527, encodeId=c3d9100252e92, content=梅斯理学物理影序号, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 17:23:47 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002437, encodeId=d5cf100243eb7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d9a5554272, createdName=shijieyanliang, createdTime=Sun Jul 25 08:01:38 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002436, encodeId=cae3100243612, content=已读已读已读已读已读已读,学习学习学习学习学习学习,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Sun Jul 25 07:27:03 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
    2021-07-26 zhaojie88
  5. [GetPortalCommentsPageByObjectIdResponse(id=2179719, encodeId=2d3c21e971958, content=学习了,受益,也试试杀菌, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJib8tnO4ohKYNgT37ibRAQ9XQwCSLBOhic0dopVqkt0rtF1Pm1zG730VxQcKFicGfMomafDlicYHcRhdg/0, createdBy=8ca81300474, createdName=zs-wwy, createdTime=Sun Jan 07 00:29:44 CST 2024, time=2024-01-07, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1811859, encodeId=0fb31811859d3, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Thu Apr 28 11:02:17 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786455, encodeId=ba6f1e86455ad, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Oct 21 04:02:17 CST 2021, time=2021-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355598, encodeId=444b1355598e8, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378796, encodeId=d7a613e87963b, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480042, encodeId=7c9c14800424c, content=<a href='/topic/show?id=f9e0530e169' target=_blank style='color:#2F92EE;'>#患者结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53071, encryptionId=f9e0530e169, topicName=患者结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=faa67597457, createdName=ms5906905816781247, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530633, encodeId=a98915306337c, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002527, encodeId=c3d9100252e92, content=梅斯理学物理影序号, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 17:23:47 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002437, encodeId=d5cf100243eb7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d9a5554272, createdName=shijieyanliang, createdTime=Sun Jul 25 08:01:38 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002436, encodeId=cae3100243612, content=已读已读已读已读已读已读,学习学习学习学习学习学习,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Sun Jul 25 07:27:03 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2179719, encodeId=2d3c21e971958, content=学习了,受益,也试试杀菌, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJib8tnO4ohKYNgT37ibRAQ9XQwCSLBOhic0dopVqkt0rtF1Pm1zG730VxQcKFicGfMomafDlicYHcRhdg/0, createdBy=8ca81300474, createdName=zs-wwy, createdTime=Sun Jan 07 00:29:44 CST 2024, time=2024-01-07, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1811859, encodeId=0fb31811859d3, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Thu Apr 28 11:02:17 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786455, encodeId=ba6f1e86455ad, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Oct 21 04:02:17 CST 2021, time=2021-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355598, encodeId=444b1355598e8, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378796, encodeId=d7a613e87963b, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480042, encodeId=7c9c14800424c, content=<a href='/topic/show?id=f9e0530e169' target=_blank style='color:#2F92EE;'>#患者结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53071, encryptionId=f9e0530e169, topicName=患者结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=faa67597457, createdName=ms5906905816781247, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530633, encodeId=a98915306337c, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002527, encodeId=c3d9100252e92, content=梅斯理学物理影序号, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 17:23:47 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002437, encodeId=d5cf100243eb7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d9a5554272, createdName=shijieyanliang, createdTime=Sun Jul 25 08:01:38 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002436, encodeId=cae3100243612, content=已读已读已读已读已读已读,学习学习学习学习学习学习,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Sun Jul 25 07:27:03 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2179719, encodeId=2d3c21e971958, content=学习了,受益,也试试杀菌, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJib8tnO4ohKYNgT37ibRAQ9XQwCSLBOhic0dopVqkt0rtF1Pm1zG730VxQcKFicGfMomafDlicYHcRhdg/0, createdBy=8ca81300474, createdName=zs-wwy, createdTime=Sun Jan 07 00:29:44 CST 2024, time=2024-01-07, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1811859, encodeId=0fb31811859d3, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Thu Apr 28 11:02:17 CST 2022, time=2022-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786455, encodeId=ba6f1e86455ad, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Thu Oct 21 04:02:17 CST 2021, time=2021-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355598, encodeId=444b1355598e8, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378796, encodeId=d7a613e87963b, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480042, encodeId=7c9c14800424c, content=<a href='/topic/show?id=f9e0530e169' target=_blank style='color:#2F92EE;'>#患者结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53071, encryptionId=f9e0530e169, topicName=患者结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=faa67597457, createdName=ms5906905816781247, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530633, encodeId=a98915306337c, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002527, encodeId=c3d9100252e92, content=梅斯理学物理影序号, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 17:23:47 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002437, encodeId=d5cf100243eb7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d9a5554272, createdName=shijieyanliang, createdTime=Sun Jul 25 08:01:38 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002436, encodeId=cae3100243612, content=已读已读已读已读已读已读,学习学习学习学习学习学习,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Sun Jul 25 07:27:03 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
    2021-07-26 sodoo
  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Sun Jul 25 07:27:03 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
    2021-07-25 ms3000001999514966

    梅斯理学物理影序号

    0

  9. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53071, encryptionId=f9e0530e169, topicName=患者结局)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=faa67597457, createdName=ms5906905816781247, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530633, encodeId=a98915306337c, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Mon Jul 26 15:02:17 CST 2021, time=2021-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002527, encodeId=c3d9100252e92, content=梅斯理学物理影序号, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 17:23:47 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002437, encodeId=d5cf100243eb7, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d9a5554272, createdName=shijieyanliang, createdTime=Sun Jul 25 08:01:38 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002436, encodeId=cae3100243612, content=已读已读已读已读已读已读,学习学习学习学习学习学习,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Sun Jul 25 07:27:03 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
    2021-07-25 shijieyanliang

    学习

    0

  10. 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    2021-07-25 ms5000000518166734

    已读已读已读已读已读已读,学习学习学习学习学习学习,受益匪浅。

    0

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