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SCI REP:血小板与淋巴细胞比值在泌尿系肿瘤患者的预后价值如何?

2017-11-13 xing.T MedSci原创

总之,较高的PLR和泌尿系统癌症患者的OS呈显著的负相关,除了膀胱癌患者外。然而,未来需要更大规模的高质量前瞻性研究来进行证实。

在以往的研究中,血小板淋巴细胞比率(PLR)与泌尿系统癌症患者的生存之间的关系并不一致。近日,Scientific reports杂志上针对这一问题发表了一篇荟萃分析文章。研究人员通过这项荟萃分析旨在评估PLR对泌尿系统肿瘤患者预后的意义。

研究人员对PubMed、EMBASE和Web of Science等数据库进行了文献检索,检索日期到2017年7月,研究人员采用纽卡斯尔渥太华量表对研究质量进行了评估。研究人员采用合并的风险比(HR)来估计尿系统肿瘤患者PLR水平与患者总体生存率(OS)以及其他生存结局之间的相关性。研究人员对不同种族、样本大小和截止值进行了亚组分析。

这项荟萃分析包含了20项高质量的研究,涉及7562名泌尿系癌症患者。研究人员发现治疗前较高水平的PLR与泌尿系统肿瘤患者的不良OS显著相关(合并的HR=1.58)。升高的PLR也与其他的生存结局相关。然而,研究人员还发现PLR与除膀胱癌以外的不同类型泌尿系统癌症患者的OS显著相关(膀胱癌HR=1.16,95%可信区间为0.96-1.41)。

总之,较高的PLR和泌尿系统癌症患者的OS呈显著的负相关,除了膀胱癌患者外。然而,未来需要更大规模的高质量前瞻性研究来进行证实。

原始出处:

Dong-Yang Li,et al. The Prognostic Value of Platelet-to-Lymphocyte Ratio in Urological Cancers: A Meta-Analysis.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-15673-2

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