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口服抗真菌药氟康唑可能导致孕妇流产

2019-02-20 不详 MedSci原创

氟康唑作为治疗阴道酵母菌感染的常用药物,被发现在怀孕期间使用与流产具有很高的相关性。

氟康唑作为治疗阴道酵母菌感染的常用药物,被发现在怀孕期间使用与流产具有很高的相关性。

局部治疗是真菌感染孕妇的一线治疗策略,但是口服氟康唑却经常被用于孕妇的治疗。

阴道酵母菌感染,也称为念珠菌病,是一种常见病。健康的阴道含有细菌和部分酵母细胞。但是当细菌和酵母的平衡发生变化时,酵母细胞就会繁殖,从而引起剧烈的瘙痒,肿胀和刺激。

研究人员统计了1998-2015年魁北克441949例孕妇数据,他们发现服用口服氟康唑与不良反应密切有关。

"我们的研究显示,口服任何剂量的氟康唑都会导致较高的流产率,"蒙特利尔大学Anick贝拉尔博士表示:"而且,在妊娠早期服用150毫克以上剂量的氟康唑与新生儿心脏缺陷的可能性增加具有相关性。"

该研究与其他研究一致,但由于研究规模仍然很小,因此需要进行更多研究。

该研究发表在加拿大医学会期刊(CMAJ)上。

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    2019-08-19 amy0563
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    2019-02-22 zhaojie88
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