Baidu
map

JAHA:小肠细菌过度生长与心力衰竭的关系及其对患者短期结局的预测

2021-03-18 MedSci原创 MedSci原创

心力衰竭患者中SIBO的患病率很高,而且SIBO与患者不良预后独立相关。积极的SIBO治疗可以为心衰患者提供额外的益处。

小肠细菌过度生长(SIBO)是一种常见的肠道菌群病理状态。SIBO的患病率及其在心力衰竭(HF)患者中的预后价值尚未明确。

近日,葛均波院士团队在血管疾病领域权威杂志JAHA上发表了一篇研究文章,他们使用乳果糖氢-甲烷呼气试验对287例患者的SIBO进行了评估。

至少满足以下标准中的1项为SIBO阳性:空腹氢水平≥20ppm (ppm)或90分钟内氢升高≥20ppm的患者诊断为SIBO (H2)阳性;随机检测甲烷水平≥10ppm的患者被诊断为SIBO (CH4)阳性。研究人员分析了SIBO与心血管死亡和心衰再住院复合结局之间的关系。

在连续就诊的287例HF患者中,128例(45%)患者SIBO阳性。研究人员的结果显示,SIBO增加了射血分数降低的心衰患者再住院风险(P<0.001),以及射血分数正常的心衰患者心血管死亡风险(P=0.011)。SIBO是HF患者主要终点的独立危险因素(风险比[HR]为2.13;95%可信区间1.26-3.58;P=0.005)。此外,SIBO (CH4)对不良预后具有预测作用(HR为2.35;95%置信区间为1.38-4.02;P<0.001),而SIBO (H2)与患者结局之间的相关性无统计学意义。

由此可见,心力衰竭患者中SIBO的患病率很高,而且SIBO与患者不良预后独立相关。积极的SIBO治疗可以为心衰患者提供额外的益处。

原始出处:

Yu Song.et al.Association of Small Intestinal Bacterial Overgrowth With Heart Failure and Its Prediction for Short‐Term Outcomes.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.119.015292

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1705281, encodeId=03611e05281e7, content=<a href='/topic/show?id=89f7e321268' target=_blank style='color:#2F92EE;'>#短期结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73212, encryptionId=89f7e321268, topicName=短期结局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=050630964579, createdName=fengyi822, createdTime=Sat Feb 26 03:14:55 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268459, encodeId=eff81268459f6, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Mar 20 14:14:55 CST 2021, time=2021-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949406, encodeId=e16f949406ef, content=任何事情过犹不及, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Mar 19 06:37:57 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1705281, encodeId=03611e05281e7, content=<a href='/topic/show?id=89f7e321268' target=_blank style='color:#2F92EE;'>#短期结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73212, encryptionId=89f7e321268, topicName=短期结局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=050630964579, createdName=fengyi822, createdTime=Sat Feb 26 03:14:55 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268459, encodeId=eff81268459f6, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Mar 20 14:14:55 CST 2021, time=2021-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949406, encodeId=e16f949406ef, content=任何事情过犹不及, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Mar 19 06:37:57 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-03-20 zhaohui6731
  3. [GetPortalCommentsPageByObjectIdResponse(id=1705281, encodeId=03611e05281e7, content=<a href='/topic/show?id=89f7e321268' target=_blank style='color:#2F92EE;'>#短期结局#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73212, encryptionId=89f7e321268, topicName=短期结局)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=050630964579, createdName=fengyi822, createdTime=Sat Feb 26 03:14:55 CST 2022, time=2022-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268459, encodeId=eff81268459f6, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Mar 20 14:14:55 CST 2021, time=2021-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949406, encodeId=e16f949406ef, content=任何事情过犹不及, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Fri Mar 19 06:37:57 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-03-19 易水河

    任何事情过犹不及

    0

相关资讯

Circ-Heart Fail:咖啡摄入量与心力衰竭风险之间的关联

咖啡摄入量的增加与HF风险降低相关。有必要进行深入研究,以更好地明确咖啡摄入量作为HF潜在可调整危险因素的作用,及其可能的因果关系和潜在机制。

心力衰竭患者,该怎么运动呢?

1. 运动的好处是什么?

JAHA:心力衰竭患者的电解剖比率与死亡率

根据体形或左心室大小标准化的QRSd电解剖比与射血分数降低的心力衰竭患者的死亡率有关。特别是,QRS/身高比值升高可能是射血分数降低的心力衰竭患者的高危标志,QRS/左心室舒张末期容量可能进一步将识。

Eur J Heart Fail:体重指数、心血管生物标志物与心力衰竭之间的关系

肥胖会影响几种心血管生物标志物的血浆浓度。只有NT-proBNP、MR-proANP和cTnT与HF发生有关,而BMI并没有改变这些关联。

JACC:经导管二尖瓣成形术治疗心力衰竭的3年预后远远优于单纯药物治疗

经导管二尖瓣成形术治疗心力衰竭的3年预后远远优于单纯药物治疗

EClinicalMedicine:合并2型糖尿病和或慢性肾病的心衰患者近20多年的预后变化趋势

心力衰竭(HF)与2型糖尿病(T2D)和慢性肾脏病(CKD)一起是二十世纪的三大主要流行病。

Baidu
map
Baidu
map
Baidu
map