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Diabetes Care:胎儿期父母吸烟增加成年后的成年女性糖尿病风险

2014-08-25 MedSci译 MedSci原创

吸烟是重要的风险因素,但是怀孕期间孕女吸烟,或其父亲吸烟,对胎儿将来生长发育影响,目前还不清楚。本研究关注这一领域,并进行了相关研究。荷兰鹿特丹Erasmus医学中心,以及哈佛医学院公共卫生营养学系Jaddoe VW教授最新一项研究阐述这一点,结果发表在最近出版的Diabetes Care上。研究人员采用Nurses' Health Study II的详细数据,这项研究共有34453名人群。通过C

吸烟是重要的风险因素,但是怀孕期间孕女吸烟,或其父亲吸烟,对胎儿将来生长发育影响,目前还不清楚。本研究关注这一领域,并进行了相关研究。

荷兰鹿特丹Erasmus医学中心,以及哈佛医学院公共卫生营养学系Jaddoe VW教授最新一项研究阐述这一点,结果发表在最近出版的Diabetes Care上。

研究人员采用Nurses' Health Study II的详细数据,这项研究共有34453名人群。通过Cox回归模型研究怀孕期间母亲与父亲吸烟与II型糖尿病事件之间的关联。

结果发现,在怀孕的第一孕期孕妇吸烟与后代的II型糖尿病风险有关,而且在控制出生体重,以及后来的BMI后,仍然显示二者的相关性。在校正年龄的模型中,怀孕期间孕妇吸烟和男性伴侣吸烟均增加后代中女儿的II型糖尿病的风险。围产期,以及成年期因素并不能解释二者的关联。不过,较正BMI后,二者关系趋势减弱。

因此,这项研究表明,
孕妇吸烟和男性伴侣吸烟均增加后代中女儿的II型糖尿病的风险。下一步还要研究在第一孕期中孕妇吸烟对后代的胰岛素抵抗的影响,评估这一风险在其中的作用。

原始出处:

Jaddoe VW, de Jonge LL, van Dam RM, Willett WC, Harris H, Stampfer MJ, Hu FB, Michels KB.Fetal Exposure to Parental Smoking and the Risk of Type 2 Diabetes in Adult Women.Diabetes Care. 2014 Aug 4. pii: DC_131679.

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    2015-04-11 x35042875

    糖尿病肾病进展风险的关系没有发现。

    0

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    2015-03-11 智智灵药
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    2014-08-26 rosa00tong

    胎儿期决定成年后健康

    0

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