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JCEM:NAFLD和/或T2DM患者的骨代谢标记物!

2018-03-03 xing.T MedSci原创

由此可见,OGTT诱导的CTX抑制在NAFLD+T2D患者中似乎有所受损,但在NAFLD或T2DM患者中保持正常,提示糖尿病和NAFLD的共存可能会影响肠-骨轴。

非酒精性脂肪性肝病(NAFLD)与2型糖尿病(T2DM)相关,反之亦然,而且两种疾病与骨折风险增加和骨代谢的改变相关。而NAFLD患者通常患有骨矿物质密度(BMD)减少症,T2DM与正常至高BMD有关。病理生理学机制尚不确定,但可能涉及肠-骨轴。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章。研究人员分析了肠道对葡萄糖诱导的血浆骨更新标志物在健康对照组和T2D患者和/或病理证实NAFLD患者的影响。

该研究采用横断面队列研究设计,纳入的受试者包括糖耐量正常的NAFLD患者、伴有T2DM的NAFLD患者和无NAFLD的T2DM患者以及健康对照者,干预为4小时50g葡萄糖耐量试验(OGTT)和同血糖的静脉输注葡萄糖(IIGI)。该研究的主要结局指标为Ⅰ型胶原(CTX)、骨钙素、Ⅰ型前胶原氨基端肽(PINP 1)和甲状旁腺激素(PTH)

OGTTs期间血浆葡萄糖水平可以与IIGI天数取得的成功匹配。NAFLD+T2DM患者具有相似的CTX抑制(P=0.46),并且在IIGI期间相比于OGTT期间P1NP发生明显的抑制。相反,OGTT期间其余组表现出更大的CTX抑制(P<0.05),在IIGI和OGTT期间,骨形成标志物表现出类似的抑制。

由此可见,OGTT诱导的CTX抑制在NAFLD+T2D患者中似乎有所受损,但在NAFLD或T2DM患者中保持正常,提示糖尿病和NAFLD的共存可能会影响肠-骨轴。

原始出处:

Henrik Maagensen,et al. Bone Turnover Markers in Patients with Non-Alcoholic Fatty Liver Disease and/or Type 2 Diabetes during Oral Glucose and Isoglycemic iv Glucose.J Clin Endocrinol Metab. 2018. https://doi.org/10.1210/jc.2018-00176

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    2018-10-07 smallant2015
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    2018-09-25 lvygwyt2781
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    2018-09-22 wjywjy
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href='/topic/show?id=ded51015e6b3' target=_blank style='color:#2F92EE;'>#骨代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101576, encryptionId=ded51015e6b3, topicName=骨代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbaa3702209, createdName=pandamao2011, createdTime=Mon Mar 05 02:20:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292757, encodeId=ec4f292e5742, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Mar 04 06:23:20 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292601, encodeId=34a6292601c1, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Mar 03 11:21:36 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-05-03 achengzhao
  5. 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  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Mar 03 11:21:36 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-17 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Mar 03 11:21:36 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-06 秀红

    学习了

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Mar 17 13:14:45 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293374, encodeId=67972933e4c4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Tue Mar 06 02:20:15 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422476, encodeId=171e14224e64a, content=<a href='/topic/show?id=ded51015e6b3' target=_blank style='color:#2F92EE;'>#骨代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101576, encryptionId=ded51015e6b3, topicName=骨代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbaa3702209, createdName=pandamao2011, createdTime=Mon Mar 05 02:20:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292757, encodeId=ec4f292e5742, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Mar 04 06:23:20 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292601, encodeId=34a6292601c1, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Mar 03 11:21:36 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
  9. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Mar 17 13:14:45 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293374, encodeId=67972933e4c4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Tue Mar 06 02:20:15 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1422476, encodeId=171e14224e64a, content=<a href='/topic/show?id=ded51015e6b3' target=_blank style='color:#2F92EE;'>#骨代谢#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101576, encryptionId=ded51015e6b3, topicName=骨代谢)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbaa3702209, createdName=pandamao2011, createdTime=Mon Mar 05 02:20:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292757, encodeId=ec4f292e5742, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sun Mar 04 06:23:20 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292601, encodeId=34a6292601c1, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Mar 03 11:21:36 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-04 121832a9m88暂无昵称

    学习了

    0

  10. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Mar 03 11:21:36 CST 2018, time=2018-03-03, status=1, ipAttribution=)]
    2018-03-03 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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