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Eur radiol:GABA含量VS.认知--MS患者中脑GABA含量与认知损伤的相关性

2017-10-25 shaosai MedSci原创

4-氨基丁酸简称GABA,性状是片状或针状结晶。广泛分布在动植物体中。植物如豆属、参属、中草药等的种子、根茎和组织液中都含有4-氨基丁酸;在动物体内,4-氨基丁酸几乎只存在于神经组织中,其中脑组织中的含量大约为0.1-0.6mg/克组织,免疫学研究表明其浓度最高的区域为大脑中黑质。本研究旨在验证复发缓解型多发性硬化(RRMS)患者较正常对照组脑内γ-氨基丁酸含量是否异常,及其与认知功能的相关性,并

4-氨基丁酸简称GABA,性状是片状或针状结晶。广泛分布在动植物体中。植物如豆属、参属、中草药等的种子、根茎和组织液中都含有4-氨基丁酸;在动物体内,4-氨基丁酸几乎只存在于神经组织中,其中脑组织中的含量大约为0.1-0.6mg/克组织,免疫学研究表明其浓度最高的区域为大脑中黑质。本研究旨在验证复发缓解型多发性硬化(RRMS)患者较正常对照组脑内γ-氨基丁酸含量是否异常,及其与认知功能的相关性,并将结果发表在Eur radiol上。

本研究共纳入了28例RRMS患者和26例健康志愿者,并行磁共振波谱成像,利用MEGA-PRESS技术检测扣带回后部(PCC)、内侧前额叶皮质(mPFC)和左侧海马的GABA信号。所有受试者均行认知评价。

与健康对照组相比,在RRMS患者中,PCC(p = 0.036)和左侧海马(p = 0.039)GABA+  含量较低。PCC和左侧海马GABA+含量降低与特异认知功能具有相关性(分别为r = -0.452、p = 0.016 ,r = 0.451、p = 0.016);mPFC中GABA+含量没有发生显着性降低,也与任何认知评分没有显着的相关性(p > 0.05)。

本研究表明,GABA能系统可能会出现RRMS的病理过程中,这表明RRMS患者中局部GABA水平与认知受损具有相关性。

原始出处:

Cao G, Edden RAE, Gao F. et al.Reduced GABA levels correlate with cognitive impairment in patients with relapsing-remitting multiple sclerosis.Eur Radiol.DOI: 10.1007/s00330-017-5064-9

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    2017-10-25 惠映实验室

    学习了.谢谢.

    0

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