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PLoS One:青少年痤疮与前列腺癌风险相关么?

2018-11-21 AlexYang MedSci原创

之前关于痤疮和前列腺癌风险关系的研究报道了并不一致的结果。最近,有研究人员进行了观察性研究的元分析来概括两者相关性的证据。研究人员在PubMed、Scopus、Web of Science和中国知网(CNKI)数据库中对文献进行了综合的搜索,截止时间到2018年,并利用随机影响模型评估了风险比(ORs)和95%置信区间(CIs),还利用了Q统计和I2指数评估了不同研究的异质性。他们的元分析总共包括

之前关于痤疮和前列腺癌风险关系的研究报道了并不一致的结果。最近,有研究人员进行了观察性研究的元分析来概括两者相关性的证据。

研究人员在PubMed、Scopus、Web of Science和中国知网(CNKI)数据库中对文献进行了综合的搜索,截止时间到2018年,并利用随机影响模型评估了风险比(ORs)和95%置信区间(CIs),还利用了Q统计和I2指数评估了不同研究的异质性。他们的元分析总共包括8个文献中报道的研究。在总的分析中,研究人员并没有发现痤疮与前列腺癌风险的相关性(OR = 1.08, 95% CI 0.93-1.25)。研究人员观察到了不同研究之间显著的异质性(P = 0.006, I2 = 64.5%)。在研究设计的亚群分析中,研究人员在研究群体中发现了显著的相关性(OR = 1.51, 95% CI 1.19-1.93),而在案例-对照研究中并没有上述相关性存在(OR = 0.98, 95% CI 0.86-1.12)。

最后,研究人员指出,他们的元分析并没有发现青少年痤疮和前列腺癌风险之间的相关性。然而,由于总分析中异质性的存在,研究群体中存在相关性。因此,良好设计的大的前瞻性研究是需要的,从而来确认上述结果。


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    2019-09-12 sjq027
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    2018-11-21 一个字-牛

    学习了谢谢分享

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