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IBD:克罗恩病患者睡得不好也会增加手术和住院风险哦!

2020-08-03 MedSci原创 MedSci原创

睡眠是人体进行自我修复的一个重要手段,因此,睡眠对于克罗恩病(CD)来说也是相当重要的。

睡眠是人体进行自我修复的一个重要手段,因此,睡眠对于克罗恩病(CD)来说也是相当重要的。的睡眠质量差与组织学活动和临床甚至有专家说你睡得好,病也就好了一半;有些病就是睡不好造成的。本项研究认为,睡眠与克罗恩病的复发有关。因此,研究人员对睡眠状况与克罗恩病的疾病进展进行了相关研究,并寻找了不良睡眠质量对住院和手术风险的影响。

 

研究人员为了进行这项实验对符合纳入排除标准的CD受试者进行了临床数据的收集,其中最重要的数据包括匹兹堡睡眠质量指数(PSQI)和哈维-布拉德肖指数(HBI)。为了探究睡眠和疾病活动度的相关性,在初次就诊和随访时均测试了PSQI和HBI的相关性。通过Kaplan-Meier和Cox比例风险比较了睡眠不良和睡眠不良的克罗恩病患者住院或手术的风险。

 

结果显示,在92名CD和82名对照受试者中,克罗恩氏病和对照受试者具有相似的基线特征和PSQI(8.3 vs 7.8,P = 0.31),并且77%的CD人群的PSQI> 5。PSQI> 5的克罗恩病患者的疾病活动度更加明显,而且睡不好的人需要更多的苯二氮卓类药物和精神科药物的使用。PSQI> 5的克罗恩病受试者还报告由于疼痛和上厕所导致更多的夜间醒来。PSQI与HBI相关(r = 0.256,P = 0.014),随访时的ΔPSQI与ΔHBI相关(r = 0.47,P = 0.002)。住院或手术的Cox比例风险模型显示PSQI> 8可预测手术或住院(风险比5.37; 95%置信区间为1.39–27.54)。

 

深度睡眠帮助身体缓解一天的劳累,CD患者睡眠质量差,负担沉重,与不良后果风险相关。睡眠质量与CD患者有并发症风险增高明显相关,并具有预测CD预后价值。

 

原始出处:

M Anthony Sofia, et al. Poor Sleep Quality in Crohn’s Disease Is Associated With Disease Activity and Risk for Hospitalization or Surgery. Inflammatory Bowel Diseases.2020.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=809115, encodeId=f8a9809115b5, content=<a href='/topic/show?id=49c3e2969ba' target=_blank style='color:#2F92EE;'>#睡眠#</a>可能对诸多疾病皆有影响,在临床研究过程中,都必需要重视睡眠的影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72969, encryptionId=49c3e2969ba, topicName=睡眠)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 15 09:56:11 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809114, encodeId=aca880911406, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>要重视全身的调控,包括睡眠。可能是因为睡眠影响了免疫功能, beContent=null, objectType=article, channel=null, level=null, likeNumber=231, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 15 09:55:36 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251731, encodeId=fdc81251e3190, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Wed Aug 05 00:05:43 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263584, encodeId=5a801263584b5, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Wed Aug 05 00:05:43 CST 2020, time=2020-08-05, status=1, ipAttribution=)]
    2020-08-15 lovetcm

    #睡眠#可能对诸多疾病皆有影响,在临床研究过程中,都必需要重视睡眠的影响

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=809115, encodeId=f8a9809115b5, content=<a href='/topic/show?id=49c3e2969ba' target=_blank style='color:#2F92EE;'>#睡眠#</a>可能对诸多疾病皆有影响,在临床研究过程中,都必需要重视睡眠的影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72969, encryptionId=49c3e2969ba, topicName=睡眠)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 15 09:56:11 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809114, encodeId=aca880911406, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>要重视全身的调控,包括睡眠。可能是因为睡眠影响了免疫功能, beContent=null, objectType=article, channel=null, level=null, likeNumber=231, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 15 09:55:36 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251731, encodeId=fdc81251e3190, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Wed Aug 05 00:05:43 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263584, encodeId=5a801263584b5, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Wed Aug 05 00:05:43 CST 2020, time=2020-08-05, status=1, ipAttribution=)]
    2020-08-15 lovetcm

    #克罗恩病#要重视全身的调控,包括睡眠。可能是因为睡眠影响了免疫功能

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=809115, encodeId=f8a9809115b5, content=<a href='/topic/show?id=49c3e2969ba' target=_blank style='color:#2F92EE;'>#睡眠#</a>可能对诸多疾病皆有影响,在临床研究过程中,都必需要重视睡眠的影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72969, encryptionId=49c3e2969ba, topicName=睡眠)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 15 09:56:11 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809114, encodeId=aca880911406, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>要重视全身的调控,包括睡眠。可能是因为睡眠影响了免疫功能, beContent=null, objectType=article, channel=null, level=null, likeNumber=231, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 15 09:55:36 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251731, encodeId=fdc81251e3190, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Wed Aug 05 00:05:43 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263584, encodeId=5a801263584b5, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Wed Aug 05 00:05:43 CST 2020, time=2020-08-05, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=809115, encodeId=f8a9809115b5, content=<a href='/topic/show?id=49c3e2969ba' target=_blank style='color:#2F92EE;'>#睡眠#</a>可能对诸多疾病皆有影响,在临床研究过程中,都必需要重视睡眠的影响, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72969, encryptionId=49c3e2969ba, topicName=睡眠)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 15 09:56:11 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=809114, encodeId=aca880911406, content=<a href='/topic/show?id=fde528896bd' target=_blank style='color:#2F92EE;'>#克罗恩病#</a>要重视全身的调控,包括睡眠。可能是因为睡眠影响了免疫功能, beContent=null, objectType=article, channel=null, level=null, likeNumber=231, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28896, encryptionId=fde528896bd, topicName=克罗恩病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 15 09:55:36 CST 2020, time=2020-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251731, encodeId=fdc81251e3190, content=<a href='/topic/show?id=fab72646628' target=_blank style='color:#2F92EE;'>#住院风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26466, encryptionId=fab72646628, topicName=住院风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93e223, createdName=bluefate121, createdTime=Wed Aug 05 00:05:43 CST 2020, time=2020-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1263584, encodeId=5a801263584b5, content=<a href='/topic/show?id=75bc930217' target=_blank style='color:#2F92EE;'>#IBD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9302, encryptionId=75bc930217, topicName=IBD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc0372, createdName=bnurmamat, createdTime=Wed Aug 05 00:05:43 CST 2020, time=2020-08-05, status=1, ipAttribution=)]
    2020-08-05 bnurmamat

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