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Gastroenterology:感染HCV对心血管疾病风险的影响

2016-01-26 Mechront 译 MedSci原创

先前关于HCV和心血管风险的研究结果具有争议,因此研究者检索了PubMed Central、Medline、Embase等数据库上比较HCV患者和非HCV患者心血管发生率,或心血管疾病患者HCV发生率相关文献,进行荟萃分析HCV感染对心血管疾病相关发病率和死亡率的影响。最终纳入了22项研究,由3名研究人员独立提取数据,使用随机效应模型进行荟萃分析。研究结果显示,与非HCV感染的患者相比,感染HCV

先前关于HCV和心血管风险的研究结果具有争议,因此研究者检索了PubMed Central、Medline、Embase等数据库上比较HCV患者和非HCV患者心血管发生率,或心血管疾病患者HCV发生率相关文献,进行荟萃分析HCV感染对心血管疾病相关发病率和死亡率的影响。

最终纳入了22项研究,由3名研究人员独立提取数据,使用随机效应模型进行荟萃分析。研究结果显示,与非HCV感染的患者相比,感染HCV会导致心血管相关死亡率的上升(OR, 1.65; 95% CI, 1.07-2.56; P = .02),颈动脉斑块风险增加(OR, 2.27; 95% CI, 1.76-2.94; P < .001),心脑血管事件风险增加 (OR, 1.30; 95% CI, 1.10-1.55; P = .002)。在HCV感染个体中关于心脑血管事件风险之间存在明显异质性,糖尿病(>10%)或高血压(>20%)发生率越高的群体,感染HCV对心脑血管疾病的风险影响就更强(OR, 1.71; 95% CI, 1.32-2.23; 两者P值均 < .001)。

荟萃分析结果表明,感染HCV会导致患者心血管相关发生率和死亡率的增加,尤其是糖尿病和高血压患者。

原始出处:

Petta S, Maida M,et al.Hepatitis C Virus Infection Is Associated With Increased Cardiovascular Mortality: A Meta-Analysis of Observational Studies.Gastroenterology. 2016 Jan;150(1):145-155.e4.


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    2016-11-17 许安
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    2016-01-29 1dd8a7c5m95(暂无匿称)

    学习!

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    2016-01-28 ymljack
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秋水仙素可能对心血管患者有益,但关于痛风患者的心血管事件研究数据稀少,本研究旨在评估痛风患者使用秋水仙素后的心血管事件发生率及全因死亡率。 研究人员分析了来自2006-2011年电子病例(EMR)数据库以及医疗索赔数据库的501名新用秋水仙素的痛风患者,并随访约16.5个月。使用秋水仙素组中有28名发生心血管事件,对照组中82名发生心血管事件,事件发生率分别为35.6/1000人年和81.8/1

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