2020CPIC 指南： CYP2C19 和质子泵抑制剂给药剂量

2022-06-01 清华大学第一附属医院药学部清华大学第一附属医院药学部

质子泵抑制剂(PPIs)广泛用于治疗和预防胃食管反流病(GERD)、胃和十二指肠溃疡、糜烂性食管炎、嗜酸细胞性食管炎、幽门螺杆菌(Hp)感染以及成人和儿童的病理性高分泌状态。大多数 PPI

中文标题：

发布机构：

清华大学第一附属医院药学部

发布日期：

2022-06-01

简要介绍：

质子泵抑制剂(PPIs)广泛用于治疗和预防胃食管反流病(GERD)、胃和十二指肠溃疡、糜烂性食管炎、嗜酸细胞性食管炎、幽门螺杆菌(Hp)感染以及成人和儿童的病理性高分泌状态。大多数 PPIs 主要经肝细胞色素 P4502C19(CYP2C19)酶广泛代谢为非活性物， CYP2C19 基因型与 PPI 暴露有关，低暴露量导致治疗失败，高暴露量有助于提高疗效。较高的 PPIs 暴露也与不良反应有关，也和 PPI 长期使用相关。本指南的目的是为临床医生提供信息，便于对 CYP2C19 基因检测结果进行解读，从而指导 PPI 类药物的开具。

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