The journal provides in-depth scholarly review articles about the care and treatment of patients with kidney failure. Emphasis is on articles related to the organ effects of uremia; benefits and complications of primary treatment methods; dialysis and transplantation; technical aspects of the delivery of uremia therapy; multidisciplinary case management of renal failure patients; care of the critically ill patient with kidney failure in the intensive care setting; new therapies for advanced kidney failure; and health care research in end-stage renal disease. Topics covered will be of interest to practicing nephrologists, nephrology fellows, nurses, technicians, dieticians and social workers caring for patients with renal disease.