Molecular Therapy Nucleic Acids is an international, open-access journal publishing top-quality basic, translational, and clinical research in the broad fields of nucleic acid-based therapeutics to treat and/or correct genetic and acquired disease. Subject areas include but are not limited to: development of therapeutics based on nucleic acids and their derivatives, vector development and design for the delivery of RNA-based therapeutics, applications of gene-modifying agents such as CRISPR/Cas9 and related technologies, pre-clinical target and biomarker validation, safety/efficacy studies, and clinical trials. Molecular Therapy Nucleic Acids Other key topics include: Applications of DNA-based oligonucleotides and their derivatives Gene vectors for delivery of RNA-based therapies Development of nanoparticles and other delivery agents siRNAs, shRNAs, saRNAs, and miRNAs Aptamers, ribozymes, and DNAzymes Peptide nucleic acids Gene-modifying technology and applications, including gene editing, base editing, and related approaches ncRNAs as therapeutic targets and biomarkers Development of new nucleic acid chemistries for altering gene expression Mechanisms of gene and nucleic acid transfer/transfection Vector trafficking and biodistribution Bioinformatic analyses