Presenting a new quarterly journal covering all aspects of the diagnosis and management of ALS (Lou Gehrig's disease), primary lateral sclerosis, spinal muscular atrophy and related motor neuron disorders. The aim of the journal is to disseminate information on new developments in the management of motor neuron disease, and enhance awareness of these devastating and often under-recognised disorders. Each issue will feature reviews, original research, case reports and short reports on all aspects of ALS, including new treatments, basic science, clinical trials, care issues, ethics and legal issues and reports from ALS centres. Features include: In-depth reviews Original research Basic science Epidemiology Clinical trials Care issues Ethics and legal issues Health economics Case reports Point-counterpoint debate Correspondence Book reviews ALS centre reports.