Aging and Disease《老化与疾病》是老年医学领域全球最具影响力的医学期刊之一，于2010年由美国International Society on Aging and Disease正式创刊。2014年获得首个影响因子3.07，2022年6月28日JCR公布期刊最新IF为9.968分，属于JCR1区。Aging and Disease是一本开放阅读的期刊，所有的文章，都可直接免费下载阅读。

Aging & Disease (A&D) is a peer reviewed, open access online journal that aspires to publish novel and high-impact findings on central issues pertaining to the biology of aging, pathophysiology of age-related diseases, and innovative therapies for diseases afflicting the elderly population. The diseases of interest include (but not limited to) Stroke, Alzheimer''''s disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes and Hypertension. Studies on animal models as well as human tissues or cells are welcome.

Manuscripts in the following areas are of particular interest:

(A) Biology of Aging:

• Mechanisms underlying changes in gene & protein expression
• Genes, mutations, signaling pathways affecting longevity and successful aging
• Mechanisms underlying stem cell proliferation, differentiation and senescence
• Role of stress at organismal and cellular levels
• Comparative mechanistic studies across species
• Efficacy of cognitive and physical exercises on longevity and aging
• Effects of dietary-supplements on longevity and aging

(B) Pathophysiology of Age-related Diseases:

• Disease pathology using cellular and molecular approaches
• Extrinsic and intrinsic factors influencing disease onset, pathology & progression
• Effects of physical exercise and environmental enrichment on disease progression

(C) Novel treatments for Diseases afflicting the elderly

• Cellular therapies using specific stem, progenitor or precursor cells
• Gene therapies using cell grafts or specific vectors
• Effects of drugs, vitamins, hormones and antioxidants for treatment of diseases