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High-Resolution Bacterial Cytological Profiling Reveals Intrapopulation Morphological Variations upon Antibiotic Exposure

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; 67 (2)

Phenotypic heterogeneity is crucial to bacterial survival and could provide insights into the mechanism of action (MOA) of antibiotics, especially tho......

Impact of Vancomycin Loading Doses and Dose Escalation on Glomerular Function and Kidney Injury Biomarkers in a Translational Rat Model

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; 67 (2)

Vancomycin-induced kidney injury is common, and outcomes in humans are well predicted by animal models. This study employed our translational rat mode......

Limited Sampling Strategies to Predict Ganciclovir Exposure after Valganciclovir Administration and to Reduce Monitoring Constraints in Renal Transplant Children

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; 67 (4)

Valganciclovir, the ganciclovir prodrug, is an antiviral agent used to prevent cytomegalovirus infection in renal transplant children. Therapeutic dru......

MarR-Dependent Transcriptional Regulation of mmpSL5 Induces Ethionamide Resistance in Mycobacterium abscessus

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; 67 (4)

Mycobacterium abscessus (Mabs) is an emerging nontuberculosis mycobacterial (NTM) pathogen responsible for a wide variety of respiratory and cutaneous......

Atazanavir Resensitizes Candida auris to Azoles

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; 67 (5)

Candida auris represents an urgent health threat. Here, we identified atazanavir as a potent drug capable of resensitizing C. auris clinical isolates ......

Frequent Emergence of Resistance Mutations Following Complex Intra-Host Genomic Dynamics in SARS-CoV-2 Patients Receiving Sotrovimab

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; 67 (7)

The emergence of the Omicron variant of SARS-CoV-2 represented a challenge to the treatment of COVID-19 using monoclonal antibodies. Only Sotrovimab m......

Case Commentary: When Voldemort Meets Sauron: Treatment Considerations for Emerging Dual-Carbapenemase-Producing Extensively Drug-Resistant Pseudomonas aeruginosa

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; 67 (7)

Infections caused by extensively drug-resistant Pseudomonas aeruginosa are difficult to treat due to limited effective treatment options. In this issu......

Multiplicity of blaKPC Genes and pKpQIL Plasmid Plasticity in the Development of Ceftazidime-Avibactam and Meropenem Coresistance in Klebsiella pneumoniae Sequence Type 307

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; 67 (8)

In 2021, Klebsiella pneumoniae sequence type 307 (ST307) strains causing pulmonary and bloodstream infections identified in a hospital in Rome, Italy,......

Disrupting the infectious disease ecosystem in the digital precision health era innovations and converging emerging technologies

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; ()

This commentary explores the convergence of precision health and evolving technologies, including the critical role of artificial intelligence (AI) an......

Safety and pharmacokinetics of SPR206 in subjects with varying degrees of renal impairment

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; ()

SPR206 is a novel polymyxin derivative with potent in vitro activity against susceptible and multidrug-resistant strains of Acinetobacter baumannii, P......

Trends in antifungal resistance in Candida from a multicenter study conducted in Madrid (CANDIMAD study): fluconazole-resistant C. parapsilosis spreading has gained traction in 2022

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; ()

We previously conducted a multicenter surveillance study on Candida epidemiology and antifungal resistance in Madrid (CANDIMAD study; 2019-2021), dete......

Simplified urine-based method to detect rifampin underexposure in adults with tuberculosis: a prospective diagnostic accuracy study

期刊: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2023; ()

Variable pharmacokinetics of rifampin in tuberculosis (TB) treatment can lead to poor outcomes. Urine spectrophotometry is simpler and more accessible......

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