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Exploring new histone deacetylase 6 inhibitors and their effects on reversing the α-tubulin deacetylation and cell morphology changes caused by methamphetamine

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (9-10)

Indazole-based HDAC6 inhibitors with novel zinc-binding modifications were synthesized and evaluated to determine their potential to inhibit HDAC6. Th......

Gastric cancer and mesenchymal stem cell-derived exosomes: from pro-tumorigenic effects to anti-cancer vehicles

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; ()

Gastric cancer (GC) is one of the most prevalent malignancies in the world, with a high mortality rate in both women and men. Conventional treatments,......

Antibody-drug conjugates and bispecific antibodies targeting cancers: applications of click chemistry

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (3)

Engineering approaches using antibody drug conjugates (ADCs) and bispecific antibodies (bsAbs) are designed to overcome the limitations of conventiona......

Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (7)

Macrophages within the tumor microenvironment (TME), referred to as tumor-associated macrophages (TAMs), are involved in various aspects of tumor prog......

Targeting dysregulated lipid metabolism in the tumor microenvironment

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; ()

The reprogramming of lipid metabolism and its association with oncogenic signaling pathways within the tumor microenvironment (TME) have emerged as si......

Phytochemistry and pharmacology of plants in the genus Chaenomeles

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; ()

Chaenomeles plants belong to the Rosaceae family and include five species, Chaenomeles speciosa (Sweet) Nakai, Chaenomeles sinensis (Thouin) Koehne, C......

Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (9-10)

The fact that mitochondria play a crucial part in energy generation has led to the nickname powerhouses of the cell being applied to them. They also p......

Naringin promotes fat browning mediated by UCP1 activation via the AMPK signaling pathway in 3T3-L1 adipocytes

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (3)

Induction of the brown adipocyte-like phenotype in white adipocytes (fat browning) is considered a promising therapeutic strategy to treat obesity. Na......

Paeoniflorin increases the survival of Pseudomonas aeruginosa infected Caenorhabditis elegans at the immunosuppression stage by activating PMK-1, BAR-1, and EGL-1 signals

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (7)

Paeoniflorin is the major active compound of total glycoside of paeony in Paeonia lactiflora Pall. Although several aspects of beneficial effects of p......

EGF, a veteran of wound healing: highlights on its mode of action, clinical applications with focus on wound treatment, and recent drug delivery strategies

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (4)

Epidermal growth factor (EGF) has been used in wound management and regenerative medicine since the late 1980s. It has been widely utilized for a long......

Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (9-10)

In a previous study, we discovered that the ethanolic extract of sea buckthorn (Hippophae rhamnoides) fruits exhibited anti-osteoporosis effects both ......

Ubiquitin-proteasome system as a target for anticancer treatment-an update

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (7)

As the ubiquitin-proteasome system (UPS) regulates almost every biological process, the dysregulation or aberrant expression of the UPS components cau......

Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (8)

Pyrrolizidine alkaloids (PAs) are potent hepatotoxins that can cause liver damage. Hyperoside (Hyp), a natural flavonoid, can be extracted from medici......

Effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide in healthy subjects

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (5)

Gliclazide metabolism is mediated by genetically polymorphic CYP2C9 and CYP2C19 enzymes. We investigated the effects of CYP2C9 and CYP2C19 genetic pol......

Synthesis of Au-Ag bimetallic nanoparticles using Korean red ginseng (Panax ginseng Meyer) root extract for chemo-photothermal anticancer therapy

期刊: ARCHIVES OF PHARMACAL RESEARCH, 2023; 46 (8)

Green synthesis strategies have been widely applied for the preparation of versatile nanomaterials. Gold nanospheres with an average size of 6.95 &amp......

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