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Apical bulkheads accumulate as adaptive response to impaired bile flow in liver disease

期刊: EMBO REPORTS, 2023; 24 (9)

Hepatocytes form bile canaliculi that dynamically respond to the signalling activity of bile acids and bile flow. Little is known about their response......

Centriolar subdistal appendages promote double-strand break repair through homologous recombination

期刊: EMBO REPORTS, 2023; 24 (10)

The centrosome is a cytoplasmic organelle with roles in microtubule organization that has also been proposed to act as a hub for cellular signaling. S......

Genome-wide association and environmental suppression of the mortal germline phenotype of wild C. elegans

期刊: EMBO REPORTS, 2023; 24 (12)

The animal germline lineage needs to be maintained along generations. However, some Caenorhabditis elegans wild isolates display a mortal germline phe......

Convergent insulin and TGF-β signalling drives cancer cachexia by promoting aberrant fat body ECM accumulation in a Drosophila tumour model

期刊: EMBO REPORTS, 2023; 24 (12)

In this study, we found that in the adipose tissue of wildtype animals, insulin and TGF-beta signalling converge via a BMP antagonist short gastrulati......

DOT1L activity affects neural stem cell division mode and reduces differentiation and ASNS expression

期刊: EMBO REPORTS, 2023; 24 (8)

Cortical neurogenesis depends on the balance between self-renewal and differentiation of apical progenitors (APs). Here, we study the epigenetic contr......

Orchestrating vesicular and nonvesicular membrane dynamics by intrinsically disordered proteins

期刊: EMBO REPORTS, 2023; 24 (11)

Compartmentalization by membranes is a common feature of eukaryotic cells and serves to spatiotemporally confine biochemical reactions to control phys......

Lipin-2 regulates the antiviral and anti-inflammatory responses to interferon

期刊: EMBO REPORTS, 2023; 24 (12)

Interferons (IFN) are crucial antiviral and immunomodulatory cytokines that exert their function through the regulation of a myriad of genes, many of ......

Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis

期刊: EMBO REPORTS, 2023; 24 (12)

Extracellular vesicles released by tumors (tEVs) disseminate via circulatory networks and promote microenvironmental changes in distant organs favorin......

Molecular view of ER membrane remodeling by the Sec61/TRAP translocon

期刊: EMBO REPORTS, 2023; 24 (12)

Protein translocation across the endoplasmic reticulum (ER) membrane is an essential step during protein entry into the secretory pathway. The conserv......

Structural study of UFL1-UFC1 interaction uncovers the role of UFL1 N-terminal helix in ufmylation

期刊: EMBO REPORTS, 2023; 24 (12)

Ufmylation plays a crucial role in various cellular processes including DNA damage response, protein translation, and ER homeostasis. To date, little ......

Mitigating the ecological collapse of coral reef ecosystems Effective strategies to preserve coral reef ecosystems

期刊: EMBO REPORTS, 2023; 24 (4)

Global warming is decimating coral reefs. We need to implement mitigation and restoration strategies now to prevent coral reefs from disappearing alto......

Non-apoptotic caspase activation ensures the homeostasis of ovarian somatic stem cells

期刊: EMBO REPORTS, 2023; 24 (6)

Current evidence has associated caspase activation with the regulation of basic cellular functions without causing apoptosis. Malfunction of non-apopt......

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