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Proinflammatory S100A9 stimulates TLR4/NF-?B signaling pathways causing enhanced phagocytic capacity of microglial cells

期刊: IMMUNOLOGY LETTERS, 2023; 255 ()

Alzheimer's disease (AD) is the main cause of dementia, affecting the increasingly aging population. Growing evidence indicates that neuro-inflammatio......

Comparison of effects of multiple adjuvants and immunization routes on the immunogenicity and protection of HSV-2 gD subunit vaccine

期刊: IMMUNOLOGY LETTERS, 2023; 260 ()

Genital herpes caused by herpes simplex virus type 2 (HSV-2) poses a global health issue. HSV-2 infection increases the risk of acquiring HIV infectio......

A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation

期刊: IMMUNOLOGY LETTERS, 2023; 263 ()

Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays multiple roles in inflammation.......

Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

期刊: IMMUNOLOGY LETTERS, 2023; 258 ()

Background: Here we assessed a possible relationship between baseline TGF-beta concentrations and acquisition of sterile immunity after Plasmodium fal......

Screening epitope peptides based on a phage-displayed random peptide and peptide microarrays to contribute to improving the diagnostic efficiency of systemic lupus erythematosus

期刊: IMMUNOLOGY LETTERS, 2023; 259 ()

Background: Systemic lupus erythematosus (SLE) is one of the most common autoimmune diseases in China. At present, there are hundreds of autoantibodie......

Elevated circulating CD19+CD24hiCD38hi B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy

期刊: IMMUNOLOGY LETTERS, 2023; 261 ()

CD19+CD24hiCD38hi regulatory B cells exert immunosuppressive functions by producing IL-10, but their role in idiopathic membranous nephropathy (IMN) r......

Immune dysregulation as a leading principle for lymphoma development in diverse immunological backgrounds

期刊: IMMUNOLOGY LETTERS, 2023; 263 ()

Lymphoma is a heterogeneous group of malignancies arising from lymphocytes, which poses a significant challenge in terms of diagnosis and treatment du......

Activation of cannabinoid receptors 2 alleviates myocardial damage in cecal ligation and puncture-induced sepsis by inhibiting pyroptosis

期刊: IMMUNOLOGY LETTERS, 2023; 264 ()

Background: It has been reported that cannabinoid receptors 2 (CB2 receptors) play an important role in the pathophysiological process of sepsis, whic......

Final step of B-cell differentiation into plasmablasts; the right time to activate plasma cell PIM2 kinase

期刊: IMMUNOLOGY LETTERS, 2023; 258 ()

The differentiation of B cells into antibody-secreting plasma cells is a complex process that involves extensive changes in morphology, lifespan, and ......

Correlation of serum adenosine deaminase activity with disease activity in patients with primary Sjogren's syndrome

期刊: IMMUNOLOGY LETTERS, 2023; 258 ()

Background: Primary Sjogren's syndrome (pSS) is a chronic inflammatory autoimmune disease primarily affecting the exocrine glands, which has a variety......

Immune cell profiles and patient clustering in complex cases of interstitial lung disease

期刊: IMMUNOLOGY LETTERS, 2023; 253 ()

Interstitial lung disease comprises numerous clinical entities posing significant challenges towards a prompt and accurate diagnosis. Amongst the cont......

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