A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation-MedSci.cn

A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation

Park, JS; Yang, S; Song, D; Kim, SM; Choi, J; Kang, HY; Jeong, HY; Han, G; Min, DS; Cho, ML; Park, SH

Cho, ML; Park, SH (通讯作者)，Catholic Univ Korea, Catholic Res Inst Med Sci, Rheumatism Res Ctr, 222 Banpo Daero, Seoul 06591, South Korea.;Park, SH (通讯作者)，Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Rheumatol, 222 Banpo Daero, Seoul 06591, South Korea.;Min, DS (通讯作者)，Yonsei Univ, Coll Pharm, 85 Songdogwahak Ro, Incheon 21983, South Korea.

Abstract

Phospholipase D1 (PLD1), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays multiple roles in inflammation.......

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A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation

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