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Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (2)

The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel and the epithelial Na+ channel (ENaC) play essential roles in transepithe......

A novel beneficial role of humanin on intestinal apoptosis and dysmotility in a rat model of ischemia reperfusion injury

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (5)

A prevalent clinical problem including sepsis, shock, necrotizing enterocolitis, and mesenteric thrombosis is intestinal ischemia/reperfusion (I/R) in......

CCE and EODF as two distinct non-shivering thermogenesis models inducing weight loss

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (8)

Increasing energy expenditure and reducing energy intake are considered two classical methods to induce weight loss. Weight loss through physical meth......

Optogenetically mediated large volume suppression and synchronized excitation of human ventricular cardiomyocytes

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (12)

A major challenge in cardiac optogenetics is to have minimally invasive large volume excitation and suppression for effective cardioversion and treatm......

What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; ()

Acidosis is a chemical signature of the tumour microenvironment that challenges intracellular pH homeostasis. The orchestrated activity of acid-base t......

Age-related increases in cardiac excitability, refractoriness and impulse conduction favor arrhythmogenesis in male rats

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (6)

The effects of excitability, refractoriness, and impulse conduction have been independently related to enhanced arrhythmias in the aged myocardium in ......

Effect of cisplatin on respiratory activity in neonatal rats

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (2)

One side effect of cisplatin, a cytotoxic platinum anticancer drug, is peripheral neuropathy; however, its central nervous system effects remain uncle......

Impact of the glutamatergic neurotransmission within the A5 region on the cardiorespiratory response evoked from the midbrain dlPAG

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (4)

Stimulation of the dorsolateral periaqueductal grey matter (dlPAG) in rats evokes an active defensive behaviour together with a cardiorespiratory resp......

Effects of aconitine on the respiratory activity of brainstem-spinal cord preparations isolated from newborn rats

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (11)

Aconitine is a sodium channel opener, but its effects on the respiratory center are not well understood. We investigated the dose-dependent effects of......

Tobacco smoking and vascular biology and function: evidence from human studies

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (7)

Tobacco cigarette smoking is among the most complex and least understood health risk factors. A deeper insight into the pathophysiological actions of ......

Comparative study of the effects of cigarette smoke versus next-generation tobacco and nicotine product extracts on inflammatory biomarkers of human monocytes

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (7)

Monocytes exhibiting a pro-inflammatory phenotype play a key role in adhesion and development of atherosclerotic plaques. As an alternative to smoking......

Skeletal muscle proteins involved in fatty acid transport influence fatty acid oxidation rates observed during exercise

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (9)

Several proteins are implicated in transmembrane fatty acid transport. The purpose of this study was to quantify the variation in fatty acid oxidation......

Functional characterization of acid-sensing ion channels in the cerebellum-originating medulloblastoma cell line DAOY and in cerebellar granule neurons

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (9)

Acid-sensing ion channels (ASICs) are Na+ channels that are almost ubiquitously expressed in neurons of the brain. Functional ASIC1a is also expressed......

Normobaric hypoxia shows enhanced FOXO1 signaling in obese mouse gastrocnemius muscle linked to metabolism and muscle structure and neuromuscular innervation

期刊: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2023; 475 (11)

Skeletal muscle relies on mitochondria for sustainable ATP production, which may be impacted by reduced oxygen availability (hypoxia). Compared with l......

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