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Metabolic checkpoint of ferroptosis resistance

期刊: MOLECULAR & CELLULAR ONCOLOGY, ; ()

The metabolic checkpoint of ferroptosis remains obscure. We find that glucose favors system xc(-) inhibitor-induced ferroptosis by activating pyruvate......

The oxidoreductases POR and CYB5R1 catalyze lipid peroxidation to execute ferroptosis

期刊: MOLECULAR & CELLULAR ONCOLOGY, 2021; 8 (2)

Our recent study showed that two oxidoreductases - NADPH-cytochrome P450 reductase (POR) and NADH-cytochrome b5 reductase (CYB5R1) - transfer electron......

Mechanical softness: a true stemness feature for cancer cells

期刊: MOLECULAR & CELLULAR ONCOLOGY, 2021; 8 (2)

Developing a method that can effectively define and sort cancer stem cells (CSCs) is extremely desirable. Mechanical stiffness is of paramount importa......

eMIONs: novel genetically engineered nanocages for magnetic hyperthermia cancer therapy

期刊: MOLECULAR & CELLULAR ONCOLOGY, 2021; 8 (1)

The clinical introduction of magnetic hyperthermia therapy (MHT) has been hindered by current available agents with poor magnetic-to-thermal conversio......

SRC promotes lipogenesis: implications for obesity and breast cancer

期刊: MOLECULAR & CELLULAR ONCOLOGY, 2021; 8 (1)

Remodeling of lipid metabolism has been implicated in cancers; however, it remains obscure how the lipid metabolic pathways are altered by oncogenic s......

Targeting ganglioneuromas with mTOR inhibitors

期刊: MOLECULAR & CELLULAR ONCOLOGY, 2021; 8 (1)

We recently identified activated protein kinase B (PKB/AKT) as a tumorigenic driver in childhood ganglioneuroma. Inhibition of the mechanistic target ......

Ketosis versus carbotoxicity - metabolism determines the outcome of cancer immunotherapy

期刊: MOLECULAR & CELLULAR ONCOLOGY, 2021; 8 (1)

Carbohydrate-rich diets have been consistently associated with detrimental effects for human health, including diabetes and obesity. Moreover, high gl......

Structure of Rad5 provides insights into its role in tolerance to replication stress

期刊: MOLECULAR & CELLULAR ONCOLOGY, 2021; 8 (2)

The Rad5 family of proteins are critical genome maintenance factors, with helicase-like transcription factor (HLTF) and SNF2 histone linker PHD RING h......

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