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Targeting ganglioneuromas with mTOR inhibitors

Tao, T; Shi, H; Durbin, AD; Look, AT

Durbin, AD (corresponding author), St Jude Childrens Res Hosp, Dept Oncol, Div Mol Oncol, 262 Danny Thomas Pl, Memphis, TN 38105 USA.; Tao, T (corresponding author), Zhejiang Univ, Childrens Hosp, Sch Med, Hangzhou 310052, Peoples R China.; Look, AT (corresponding author), Dana Farber Canc Inst, Dept Pediat Oncol, 450 Brookline Ave, Boston, MA 02215 USA.

MOLECULAR & CELLULAR ONCOLOGY, 2021; 8 (1):

Abstract

We recently identified activated protein kinase B (PKB/AKT) as a tumorigenic driver in childhood ganglioneuroma. Inhibition of the mechanistic target ......

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