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Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension

期刊: SKELETAL MUSCLE, 2022; 12 (1)

Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk of mortality. G......

JIF:4.319

Oxidative stress-induced premature senescence and aggravated denervated skeletal muscular atrophy by regulating progerin-p53 interaction

期刊: SKELETAL MUSCLE, 2022; 12 (1)

Background Progerin elevates atrophic gene expression and helps modify the nuclear membrane to cause severe muscle pathology, which is similar to musc......

JIF:4.319

Identification of the co-differentially expressed hub genes involved in the endogenous protective mechanism against ventilator-induced diaphragm dysfunction

期刊: SKELETAL MUSCLE, 2022; 12 (1)

Background In intensive care units (ICU), mechanical ventilation (MV) is commonly applied to save patients' lives. However, ventilator-induced diaphra......

JIF:4.319

Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release

期刊: SKELETAL MUSCLE, 2021; 11 (1)

Background: Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the ......

Niclosamide ethanolamine ameliorates diabetes-related muscle wasting by inhibiting autophagy

期刊: SKELETAL MUSCLE, 2021; 11 (1)

Background Diabetes-related muscle wasting is one of the devastating complications of diabetes, which is associated with muscle autophagy due to insul......

Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study

期刊: SKELETAL MUSCLE, 2021; 11 (1)

Background Old age is associated with a significantly increased mortality in COVID-19 patients exposed to long-term controlled mechanical ventilation ......

Muscle atrophy induced by overexpression of ALAS2 is related to muscle mitochondrial dysfunction

期刊: SKELETAL MUSCLE, 2021; 11 (1)

Background ALAS2 (delta-aminolevulinate synthase 2) is one of the two isoenzymes catalyzing the synthesis of delta-aminolevulinic acid (ALA), which is......

MiR-1290 promotes myoblast differentiation and protects against myotube atrophy via Akt/p70/FoxO3 pathway regulation

期刊: SKELETAL MUSCLE, 2021; 11 (1)

Background Sarcopenia is a common skeletal disease related to myogenic disorders and muscle atrophy. Current clinical management has limited effective......

Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway

期刊: SKELETAL MUSCLE, 2020; 10 (1)

Background Elderly populations are susceptible to critical limb ischemia (CLI), but conventional treatments cannot significantly decrease amputation a......

Metabolic derangements of skeletal muscle from a murine model of glioma cachexia

期刊: SKELETAL MUSCLE, 2019; 9 ()

BackgroundCachexia is a complex metabolic disorder and muscle atrophy syndrome, impacting 80% patients with advanced cancers. Malignant glioma is cons......

JIF:4.0

Two functional variants at 6p21.1 were associated with lean mass

期刊: SKELETAL MUSCLE, 2019; 9 (1)

Background Low lean body mass is the most important predictor of sarcopenia with strong genetic background. The aim of this study was to uncover genet......

JIF:4.0

IMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway

期刊: SKELETAL MUSCLE, 2019; 9 ()

BackgroundCancer cachexia as a metabolic syndrome can lead to at least 25% of cancer deaths. The inhibition of muscle atrophy is a main strategy to tr......

JIF:4.0

Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells

期刊: SKELETAL MUSCLE, 2019; 9 ()

BackgroundEstrogen signaling is indispensable for muscle regeneration, yet the role of estrogen in the development of muscle inflammation, especially ......

JIF:4.0

Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats

期刊: SKELETAL MUSCLE, 2018; 8 ()

Background: A low-protein diet supplemented with ketoacids (LPD + KA) maintains the nutritional status of patients with chronic kidney disease (CKD). ......

JIF:4.0

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