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Role of the preoperative circulating tumor DNA KRAS mutation in patients with resectable pancreatic cancer

期刊: PHARMACOGENOMICS, 2021; 22 (11)

Aim: The prognosis of resectable pancreatic cancer patients with the same stage of disease is highly variable. The purpose of this study is to establi......

Evolution and functional divergence of the ERBB receptor family

期刊: PHARMACOGENOMICS, 2021; 22 (8)

Aim: The ERBB gene family plays an important role in cell proliferation and differentiation, and aberrant activations could result in tumorigenesis, w......

Genetic variants of PEAR1 and ischemic clinical outcomes in coronary artery disease patients: a systematic review and meta-analysis

期刊: PHARMACOGENOMICS, 2021; 22 (10)

Aim: The aim of this study was to assess the association between PEAR1 polymorphisms and ischemic clinical outcomes. Materials & methods: We searc......

Influence of CYP2D6 gene polymorphisms on the pharmacokinetics of aripiprazole in healthy Chinese subjects

期刊: PHARMACOGENOMICS, 2021; 22 (04)

Background: Pharmacogenetics study was added into 2 bioequivalence trials of aripiprazole. The correlation between CYP2D6 polymorphisms and aripiprazo......

Effects of EPHX1 rs2260863 polymorphisms on warfarin maintenance dose in very elderly, frail Han-Chinese population

期刊: PHARMACOGENOMICS, 2020; 21 (12)

Aim: This study was conducted to investigate the effects of VKORC1, CYP2C9, CYP4F2 and EPHX1 and non-genetic factors on warfarin maintenance dose in a......

Association between genetic polymorphism and antidepressants in major depression: a network meta-analysis

期刊: PHARMACOGENOMICS, 2020; 21 (13)

This network meta-analysis was conducted to compare the predictive value of eight SNPs on the efficacy of antidepressants in major depressive disorder......

Pharmacogenomics and pharmacokinetics of efavirenz 400 or 600 mg in 184 treatment-naive HIV-infected patients in China

期刊: PHARMACOGENOMICS, 2020; 21 (13)

Background:The pharmacogenomics and pharmacokinetics/pharmacodynamics of 400 mg efavirenz have rarely been reported.Materials & methods:A total of......

A potential role for the CDH13/CDH15 gene in repeat revascularization after first percutaneous coronary intervention

期刊: PHARMACOGENOMICS, 2020; 21 (2)

Aim: Major drawbacks of percutaneous coronary intervention are the high occurrence of repeat revascularization due to restenosis and disease progressi......

Impact of CYP2C9, VKORC1, ApoE and ABCB1 polymorphisms on stable warfarin dose requirements in elderly Chinese patients

期刊: PHARMACOGENOMICS, 2020; 21 (2)

Aim: To analyze the impact of nongenetic factors and gene polymorphisms on warfarin dose requirements in elderly Shanghai Han Chinese patients. Materi......

CYP2D6*10 pharmacogenetic-guided SERM could be a cost-effective strategy in Chinese patients with hormone receptor-positive breast cancer

期刊: PHARMACOGENOMICS, 2020; 21 (1)

Aim: To assess the cost-effectiveness of CYP2D6*10 genetic testing for the management of Chinese women with hormone receptor-positive (HR+) breast can......

Cost-effectiveness of CYP2C19 LOF-guided antiplatelet therapy in Chinese patients with acute coronary syndrome

期刊: PHARMACOGENOMICS, 2020; 21 (1)

Aim: This study aimed to evaluate the cost-effectiveness of CYP2C19 loss-of-function(LOF) allele-guided antiplatelet therapy compared with the univers......

Comparison of the prediction performance of different warfarin dosing algorithms based on Chinese patients

期刊: PHARMACOGENOMICS, 2020; 21 (1)

Aim: To compare the prediction performance of different warfarin dosing algorithms based on Chinese patients. Materials & methods: A total of 18 a......

Evaluation of clinical impact of pharmacogenomics knowledge involved in CPIC guidelines on Chinese pediatric patients

期刊: PHARMACOGENOMICS, 2020; 21 (3)

Aim: To evaluate the clinical benefits of implementing pharmacogenomics testing for Chinese pediatric patients. Materials & methods : Based on the......

microRNA-137 downregulates MCL1 in ovarian cancer cells and mediates cisplatin-induced apoptosis

期刊: PHARMACOGENOMICS, 2020; 21 (3)

Aim: miR-137 is downregulated in various cancers; however, its function in ovarian cancer remains unclear. Methods: The roles of miR-137 in apoptosis ......

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