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5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivative attenuates lupus nephritis with less effect to thymocyte development

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (4)

Retinoic-acid-receptor-related orphan nuclear hormone receptor gamma t (ROR gamma t), a critical transcriptional factor of Th17 cells, is a potential ......

Activation of autophagy reverses gemcitabine-induced immune inhibition of RAW264.7 macrophages by promoting TNF-alpha, IL-6 and MHC-II expression

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (4)

This research aims to investigate the effect of gemcitabine (GEM) on various activities and functions of macrophages. Phagocytosis, cell autophagy and......

Role of clinicopathological features for the early prediction of prognosis in lupus nephritis

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (3)

Ambiguities remain regarding the role of clinicopathological characteristics in the early prediction of the prognosis of lupus nephritis (LN). Systemi......

The intervention of intestinal Wnt/beta-catenin pathway alters inflammation and disease severity of CIA

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (4)

Autoreactive T cell is one of the leading causes of immunological tolerance defects in the chronic inflammatory lesions of rheumatoid arthritis (RA). ......

Recent advances in the role of Th17/Treg cells in tumor immunity and tumor therapy

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (5)

Th17 and Treg cells play an important role in regulating tissue inflammation and maintaining the stability of the immune system. They regulate inflamm......

Immunoglobulin G4-related disease: case report and literature review

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (5)

Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a rare and chronic progressive clinical entity, characterized by elevated serum IgG4 along with ti......

Helios serves as a suppression marker to reduce regulatory T cell function in pancreatic cancer patients

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (3)

Destabilizing and reprogramming regulatory T (Treg) cells have become a potential strategy to treat tumor. Mounting evidence indicates that the transc......

Inhibition of the p38 MAPK pathway attenuates renal injury in pregnant rats with acute necrotizing pancreatitis

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (3)

The p38 mitogen-activated protein kinase (MAPK) pathway is an important intracellular signalling pathway that leads to increased expression of pro-inf......

Late-onset autoimmune polyendocrine syndrome type 1: a case report and literature review

期刊: IMMUNOLOGIC RESEARCH, ; ()

Autoimmune polyendocrine syndrome type 1 (APS-1), also referred to as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), a rare ......

Dysregulation of circulating follicular helper T cells in type 2 diabetic patients with diabetic retinopathy

期刊: IMMUNOLOGIC RESEARCH, ; ()

Inflammation is known to be involved in the progression of diabetic retinopathy. Follicular helper T cells (Tfh) play critical roles in the differenti......

Dexmedetomidine alleviates pulmonary edema through the epithelial sodium channel (ENaC) via the PI3K/Akt/Nedd4-2 pathway in LPS-induced acute lung injury

期刊: IMMUNOLOGIC RESEARCH, ; ()

Dexmedetomidine (Dex), a highly selective alpha(2)-adrenergic receptor (alpha(2)AR) agonist, has an anti-inflammatory property and can alleviate pulmo......

Effects of functionally diverse calpain system on immune cells

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (1)

Calpains are a family of nonlysosomal cysteine proteases, which play important roles in numerous physiological and pathological processes. Locations o......

Humoral immune response to epidermal growth factor receptor in lung cancer

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (1)

The aim of this study was to explore the potential value of autoantibody to epidermal growth factor receptor (EGFR) in the diagnosis of lung cancer (L......

Autoimmune liver disease-associated serologic profiling in Chinese patients with acute hepatitis E virus infection

期刊: IMMUNOLOGIC RESEARCH, 2021; 69 (1)

The association between hepatitis E virus (HEV) and autoimmune liver diseases has been well-researched; however, the focus has been on autoimmune hepa......

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