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Genetic support of a causal relationship between iron status and atrial fibrillation: a Mendelian randomization study

期刊: GENES AND NUTRITION, 2022; 17 (1)

Background Atrial fibrillation is the most common arrhythmia disease. Animal and observational studies have found a link between iron status and atria......

JIF:5.138

Interactions of CDKAL1 rs7747752 polymorphism and serum levels of L-carnitine and choline are related to increased risk of gestational diabetes mellitus

期刊: GENES AND NUTRITION, 2022; 17 (1)

Background Interactions between genetic, metabolic, and environmental factors lead to gestational diabetes mellitus (GDM). We aimed to examine interac......

JIF:5.138

Gut microbiota in patients with obesity and metabolic disorders - a systematic review

期刊: GENES AND NUTRITION, 2022; 17 (1)

Background Previous observational studies have demonstrated inconsistent and inconclusive results of changes in the intestinal microbiota in patients ......

JIF:5.138

Mendelian randomization analysis of vitamin D in the secondary prevention of hypertensive-diabetic subjects: role of facilitating blood pressure control

期刊: GENES AND NUTRITION, 2022; 17 (1)

Background Vitamin D (Vit-D) promotes vascular repair and its deficiency is closely linked to the development of type 2 diabetes mellitus (T2DM) and h......

JIF:5.138

Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma

期刊: GENES AND NUTRITION, 2022; 17 (1)

Background Cancer therapy targeting programmed death receptor-1 (PD-1 or CD279) or programmed death-ligand 1 (PD-L1 or CD274) gives hope to Tongue Squ......

JIF:5.138

MicroRNA-205-5p plays a suppressive role in the high-fat diet-induced atrial fibrosis through regulation of the EHMT2/IGFBP3 axis

期刊: GENES AND NUTRITION, 2022; 17 (1)

Objective: MicroRNAs (miRNAs) targeting has been revealed to be an appealing strategy for the treatment and management of atrial fibrillation (AF). In......

JIF:5.138

Serum iron status and the risk of breast cancer in the European population: a two-sample Mendelian randomisation study

期刊: GENES AND NUTRITION, 2021; 16 (1)

Background Previous observational studies have provided conflicting results on the association between serum iron status and the risk of breast cancer......

Expression of the circular RNAs in astaxanthin promotes cholesterol efflux from THP-1 cells based on RNA-seq

期刊: GENES AND NUTRITION, 2021; 16 (1)

Background It is reported that circular RNAs (circRNAs) play a key role in atherosclerosis (AS). Foam cell formation, which is the main feature of AS,......

Association of vitamin D pathway genes polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population

期刊: GENES AND NUTRITION, 2021; 16 (1)

Objective: This study aimed to evaluate the association of single nucleotide polymorphisms (SNPs) of vitamin D metabolic pathway genes with susceptibi......

TCONS_00230836 silencing restores stearic acid-induced beta cell dysfunction through alleviating endoplasmic reticulum stress rather than apoptosis

期刊: GENES AND NUTRITION, 2021; 16 (1)

Background: Chronic exposure of pancreatic beta cells to high levels of stearic acid (C18:0) leads to impaired insulin secretion, which accelerates th......

Maternal folic acid impacts DNA methylation profile in male rat offspring implicated in neurodevelopment and learning/memory abilities

期刊: GENES AND NUTRITION, 2021; 16 (1)

Background Periconceptional folic acid (FA) supplementation not only reduces the incidence of neural tube defects, but also improves cognitive perform......

Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese

期刊: GENES AND NUTRITION, 2021; 16 (1)

Background and objectives Previous studies have found the important gene-diet interactions on type 2 diabetes (T2D) incident but have not followed bra......

Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice

期刊: GENES AND NUTRITION, 2020; 15 (1)

Background Adiponectin and resistin are typically secreted by the adipose tissue and are abnormally expressed in obesity. However, the underlying infl......

Moderately high folate level may offset the effects of aberrant DNA methylation of P16 and P53 genes in esophageal squamous cell carcinoma and precancerous lesions

期刊: GENES AND NUTRITION, 2020; 15 (1)

Background This study evaluated gene-nutrition interactions between folate and the aberrant DNA methylation of tumor suppressor genes in different sta......

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