期刊： BIOMOLECULES & THERAPEUTICS, 2021; 29 (1)
Hsp90 is often overexpressed with activated form in cancer cells, and many key cellular proteins are dependent upon the Hsp90 machinery (these protein......
期刊： BIOMOLECULES & THERAPEUTICS, 2021; 29 (2)
Cereblon (CRBN), a substrate receptor of cullin 4-RING E3 ligase (CRL4) regulates the ubiquitination and degradation of c-Jun, mediating the lipopolys......
期刊： BIOMOLECULES & THERAPEUTICS, 2021; 29 (5)
Thyroid cancer is the most common endocrine malignancy. Patients with well-differentiated thyroid cancers, such as papillary and follicular cancers, h......
期刊： BIOMOLECULES & THERAPEUTICS, 2021; 29 (2)
Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). ......
期刊： BIOMOLECULES & THERAPEUTICS, 2021; 29 (2)
The mitogen-activated protein kinase (MAPK) pathway controls intestinal epithelial barrier permeability by regulating tight junctions (TJs) and epithe......
期刊： BIOMOLECULES & THERAPEUTICS, 2021; 29 (5)
In a search for effective PPAR-gamma agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected......
期刊： BIOMOLECULES & THERAPEUTICS, 2020; 28 (3)
The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer's disease (AD) driven b......
期刊： BIOMOLECULES & THERAPEUTICS, 2020; 28 (4)
In current study, we aimed to investigate whether the gentiopicroside (GPS) derived from Gentiana manshurica Kitagawa could block the progression of a......
期刊： BIOMOLECULES & THERAPEUTICS, 2020; 28 (2)
Silibinin exhibits antidiabetic potential by preserving the mass and function of pancreatic beta-cells through up-regulation of estrogen receptor-alph......
期刊： BIOMOLECULES & THERAPEUTICS, 2019; 27 (1)
Previous studies have shown that spinosin was implicated in the modulation of sedation and hypnosis, while its effects on learning and memory deficits......
期刊： BIOMOLECULES & THERAPEUTICS, 2019; 27 (1)
Cis-3-O-p-hydroxycinnamoyl ursolic acid (HCUA), a triterpenoid compound, was purified from Elaeagnus oldhamii Maxim. This traditional medicinal plant ......
期刊： BIOMOLECULES & THERAPEUTICS, 2019; 27 (2)
Depression is a major mood disorder. Abnormal expression of glial glutamate transporter-1 (GLT-1) is associated with depression. Schisantherin B (STB)......
期刊： BIOMOLECULES & THERAPEUTICS, 2019; 27 (2)
Intestinal barrier dysfunction always accompanies cirrhosis in patients with advanced liver disease and is an important contributor facilitating bacte......
期刊： BIOMOLECULES & THERAPEUTICS, 2019; 27 (4)
There is accumulating evidence that microRNAs are emerging as pivotal regulators in the development and progression of neuropathic pain. MicroRNA-15a/......
期刊： BIOMOLECULES & THERAPEUTICS, 2019; 27 (5)
This study sought to evaluate the effects of Asiatic acid in LPS-induced BV2 microglia cells and 1-methyl-4-phenyl-pyridine (MPP+)-induced SH-SY5Y cel......
