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Vanillin oxime inhibits lung cancer cell proliferation and activates apoptosis through JNK/ERK-CHOP pathway

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (4)

Lung cancer despite advancement in the medical field continues to be a major threat to human lives and accounts for a high proportion of fatalities ca......

Sitagliptin attenuates endothelial dysfunction independent of its blood glucose controlling effect

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (5)

Although the contributions of sitagliptin to endothelial dysfunction in diabetes mellitus were previously reported, the mechanisms still undefined. Au......

5-HT1A receptors mediate the analgesic effect of rosavin in a mouse model of oxaliplatin-induced peripheral neuropathic pain

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (5)

Oxaliplatin, a third-generation platinum derivative, is the mainstay of current antineoplastic medications for advanced colorectal cancer therapy. How......

Protective effects and mechanism of coenzyme Q10 and vitamin C on doxorubicin-induced gastric mucosal injury and effects of intestinal flora

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (4)

Doxorubicin (Dox) is widely used to the treatment of cancer, however, it could cause damage to gastric mucosa. To investigate the protective effects a......

Hydrogen sulfide restores cardioprotective effects of remote ischemic preconditioning in aged rats via HIF-1 alpha/Nrf2 signaling pathway

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (3)

The present study explored the therapeutic potential of hydrogen sulfide (H2S) in restoring aging-induced loss of cardioprotective effect of remote is......

Whole body hypoxic preconditioning-mediated multiorgan protection in db/db mice via nitric oxide-BDNF-GSK-3 beta-Nrf2 signaling pathway

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (4)

The beneficial effects of hypoxic preconditioning are abolished in the diabetes. The present study was designed to investigate the protective effects ......

Paeoniflorin ameliorates neuropathic pain-induced depression-like behaviors in mice by inhibiting hippocampal neuroinflammation activated via TLR4/NF-kappa B pathway

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (3)

Neuropathic pain (NP) that contributes to the comorbidity between pain and depression is a clinical dilemma. Neuroinflammatory responses are known to ......

Gastroprotective effect of cirsilineol against hydrochloric acid/ ethanol-induced gastric ulcer in rats

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (5)

This study was designed to evaluate the gastroprotective activity of cirsilineol in hydrochloric acid (HCl)/ethanol-induced gastric ulcer model. Cirsi......

Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (5)

Apoptosis is proved responsible for renal damage during ischemia/reper fusion. The regulation for renal apoptosis induced by ischemia/reper fusion inj......

Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (4)

The intestinal barrier function disrupted in sepsis, while little is known about the variation in different phases of sepsis. In this study, mouse mod......

Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-kappa B inhibition in macrophages

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (5)

Extended inflammation and cytokine production pathogenically contribute to a number of inflammatory disorders. Formosanin C (FC) is the major diosgeni......

NOX4/Src regulates ANP secretion through activating ERK1/2 and Akt/GATA4 signaling in beating rat hypoxic atria

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (2)

Nicotinamide adenine dinucleotide phosphate oxidases (NOXs) are the major enzymatic source of reactive oxygen species (ROS). NOX2 and NOX4 are express......

Puerarin pretreatment attenuates cardiomyocyte apoptosis induced by coronary microembolization in rats by activating the PI3K/Akt/GSK-3 beta signaling pathway

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (2)

Coronary microembolization (CME) is associated with cardiomyocyte apoptosis and cardiac dysfunction. Puerarin confers protection against multiple card......

Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-beta/p38/MK2 signaling pathway

期刊: KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2021; 25 (2)

Aging is the process spontaneously occurred in living organisms. Cardiac fibrosis is a pathophysiological process of cardiac aging. Mangiferin is a we......

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