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A Novel DNA Aptamer Targeting S100P Induces Antitumor Effects in Colorectal Cancer Cells

期刊: NUCLEIC ACID THERAPEUTICS, 2020; 30 (6)

Colorectal cancer (CRC) is a prevalent malignancy with poor prognosis and survival. As a Ca(2+)binding protein, S100P plays a role in calcium-dependen......

Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1

期刊: NUCLEIC ACID THERAPEUTICS, 2019; 29 (2)

Primary Hyperoxaluria Type 1 (PH1) is an autosomal recessive disorder of glyoxylate metabolism. Loss of alanine glyoxylate aminotransferase (AGT) func......

JIF:3.78

Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes

期刊: NUCLEIC ACID THERAPEUTICS, 2019; 29 (6)

The trinucleotide repeat containing 6 (TNRC6) family of proteins are core components of RNA interference (RNAi) and consist of three paralogs (TNRC6A,......

JIF:3.78

The BACE1-Specific DNA Aptamer A1 Rescues Amyloid-beta Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease

期刊: NUCLEIC ACID THERAPEUTICS, 2019; 29 (6)

Amyloid-beta (A beta) plaque deposits in the brain are considered to be one of the main pathological markers of Alzheimer's disease (AD). The sequenti......

JIF:3.78

An Integrative Multi-Omics Analysis Reveals MicroRNA-143 as Potential Therapeutics to Attenuate Retinal Angiogenesis

期刊: NUCLEIC ACID THERAPEUTICS, 2022; 32 (4)

Retinal neovascularization is a severe complication of proliferative diabetic retinopathy (PDR). MicroRNAs (miRNAs) are master regulators of gene expr......

JIF:4.922

Antisense Oligonucleotides Targeting Raf-1 Block Japanese Encephalitis Virus In Vitro and In Vivo

期刊: NUCLEIC ACID THERAPEUTICS, 2017; 27 (2)

Japanese encephalitis virus (JEV) infections represent a major health concern in Southeast Asia since no effective treatments are available. Recently,......

JIF:2.62

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