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Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1

Kukreja, A; Lasaro, M; Cobaugh, C; Forbes, C; Tang, JP; Gao, X; Martin-Higueras, C; Pey, AL; Salido, E; Sobolov, S; Subramanian, RR

Kukreja, A (reprint author), Alexion Pharmaceut Inc, Res, New Haven, CT USA.; Kukreja, A (reprint author), Alexion Pharmaceut Inc, 100 Coll St, New Haven, CT 06510 USA.

NUCLEIC ACID THERAPEUTICS, 2019; 29 (2): 104

Abstract

Primary Hyperoxaluria Type 1 (PH1) is an autosomal recessive disorder of glyoxylate metabolism. Loss of alanine glyoxylate aminotransferase (AGT) func......

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