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Suppression of liver transplant rejection by anti-donor MHC antibodies via depletion of donor immunogenic dendritic cells

期刊: INTERNATIONAL IMMUNOLOGY, 2021; 33 (5)

Background: We previously found two distinct passenger dendritic cell (DC) subsets in the rat liver that played a central role in the liver transplant......

Sjogren's syndrome-associated SNPs increase GTF2I expression in salivary gland cells to enhance inflammation development

期刊: INTERNATIONAL IMMUNOLOGY, 2021; 33 (8)

Sjogren's syndrome (SS) is an autoimmune disease characterized by inflammation with lymphoid infiltration and destruction of the salivary glands. Alth......

IgG immune complexes with Staphylococcus aureus protein A enhance osteoclast differentiation and bone resorption by stimulating Fc receptors and TLR2

期刊: INTERNATIONAL IMMUNOLOGY, 2020; 32 (2)

Staphylococcus aureus is a main pathogen of osteomyelitis and protein A is a virulence factor with high affinity for IgG. In this study, we investigat......

Clinical importance of the expression of CD4(+)CD8(+) T cells in renal cell carcinoma

期刊: INTERNATIONAL IMMUNOLOGY, 2020; 32 (5)

Objective CD4(+)CD8(+) T cells are expressed in some cancer patients including those with renal cell carcinoma (RCC). However, no reports have mention......

Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation

期刊: INTERNATIONAL IMMUNOLOGY, 2020; 32 (5)

Chronic allograft rejection is the most common cause of long-term allograft failure. One reason is that current diagnostics and therapeutics for chron......

Deficiency of TGR5 exacerbates immune-mediated cholestatic hepatic injury by stabilizing the beta-catenin destruction complex

期刊: INTERNATIONAL IMMUNOLOGY, 2020; 32 (5)

Intrahepatic cholestasis induced by drug toxicity may cause cholestatic hepatic injury (CHI) leading to liver fibrosis and cirrhosis. The G protein-co......

Sestrin3 enhances macrophage-mediated generation of T helper 1 and T helper 17 cells in a mouse colitis model

期刊: INTERNATIONAL IMMUNOLOGY, 2020; 32 (6)

Intestinal macrophages participate in the pathogenesis of inflammatory bowel diseases (IBDs) through secreting pro-inflammatory and tissue-damaging fa......

PD-1(+) Tim3(+) tumor-infiltrating CD8 T cells sustain the potential for IFN-gamma production, but lose cytotoxic activity in ovarian cancer

期刊: INTERNATIONAL IMMUNOLOGY, 2020; 32 (6)

Persistent exposure to tumor antigens results in exhausted tumor-infiltrating T cells (TILs) that express the immune checkpoint molecules, PD-1 and Ti......

Impaired mucociliary motility enhances antigen-specific nasal IgA immune responses to a cholera toxin-based nasal vaccine

期刊: INTERNATIONAL IMMUNOLOGY, 2020; 32 (8)

Nasal mucosal tissues are equipped with physical barriers, mucus and cilia, on their surface. The mucus layer captures inhaled materials, and the cili......

Increased urinary exosomal SYT17 levels in chronic active antibody-mediated rejection after kidney transplantation via the IL-6 amplifier

期刊: INTERNATIONAL IMMUNOLOGY, 2020; 32 (10)

Chronic active antibody-mediated rejection (CAAMR) is a particular problem in kidney transplantation (KTx), and similar to 25% of grafts are lost by C......

A high-fat diet aggravates osteonecrosis through a macrophage-derived IL-6 pathway

期刊: INTERNATIONAL IMMUNOLOGY, 2019; 31 (4)

Inflammation plays an important role in osteonecrosis. Obesity, a risk factor for osteonecrosis, leads to a chronic inflammatory status. We hypothesiz......

JIF:4.17

Respiratory syncytial virus F and G protein core fragments fused to HBsAg-binding protein (SBP) induce a T(h)1-dominant immune response without vaccine-enhanced disease

期刊: INTERNATIONAL IMMUNOLOGY, 2019; 31 (4)

The induction of a dominant T(h)2-type response is the main cause of harmful inflammation in respiratory syncytial virus (RSV) vaccine trials. A balan......

JIF:4.17

Natural killer cells kill Burkholderia cepacia complex via a contact-dependent and cytolytic mechanism

期刊: INTERNATIONAL IMMUNOLOGY, 2019; 31 (6)

Burkholderia cepacia complex (Bcc), which includes B. cenocepacia and B. multivorans, pose a life-threatening risk to patients with cystic fibrosis. E......

JIF:4.17

Faecalibacterium prausnitzii produces butyrate to decrease c-Myc-related metabolism and Th17 differentiation by inhibiting histone deacetylase 3

期刊: INTERNATIONAL IMMUNOLOGY, 2019; 31 (8)

Decreased levels of Faecalibacterium prausnitzii (F. prausnitzii), whose supernatant plays an anti-inflammatory effect, are frequently found in inflam......

JIF:4.17

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