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Deficiency of TGR5 exacerbates immune-mediated cholestatic hepatic injury by stabilizing the beta-catenin destruction complex

Rao, JH; Yang, C; Yang, SK; Lu, H; Hu, YC; Lu, L; Cheng, F; Wang, XH

Cheng, F; Wang, XH (corresponding author), Nanjing Med Univ, Hepatobiliary Ctr, Affiliated Hosp 1, Nanjing 210029, Peoples R China.; Cheng, F; Wang, XH (corresponding author), Chinese Acad Med Sci, Key Lab Liver Transplantat, Nanjing 210029, Peoples R China.; Cheng, F; Wang, XH (corresponding author), NHC Key Lab Living Donor Liver Transplantat, Nanjing 210029, Peoples R China.

INTERNATIONAL IMMUNOLOGY, 2020; 32 (5): 321

Abstract

Intrahepatic cholestasis induced by drug toxicity may cause cholestatic hepatic injury (CHI) leading to liver fibrosis and cirrhosis. The G protein-co......

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