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Determination of Impurities in Perampanel Bulk Drugs by High-Performance Liquid Chromatography and Gas Chromatography

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (7)

Background: High-Performance Liquid Chromatography (HPLC) method has been used to detect related impurities of perampanel. However, the detection of i......

Diagnosis Model of Hydrogen Sulfide Poisoning Based on Support Vector Machine

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (8)

Introduction: Hydrogen sulfide (H2S) is a lethal environmental and industrial poison. The mortality rate of occupational acute H2S poisoning reported ......

Systematical Characterization of Impurity Profiles in Daptomycin Raw Material by 2-Dimentional HPLC Tandem with MS Detector

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (7)

Objective: To systematically characterize the impurity profile in Daptomycin raw material by 2 Dimensional LC/MSn. Methods: The target impurity was se......

Characterization of an Unknown Impurity in Indobufen Tablets by HPLC-Q-TOF MS and NMR

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (7)

Background: Indobufen is a drug that hinders the aggregation of platelets by reversibly repressing the cyclooxygenase enzyme, further bringing about d......

Determination of three Unsaturated Fatty Acids in Pressure Ulcer Rats

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (8)

Background: The serum levels of Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid (EPA) and Arachidonic Acid (AA) under the state of Pressure Ulcers (......

UPLC-MS/MS Determination of Chlorogenic Acid, Hyperoside and Astragalin in Plasma and its Pharmacokinetic Application in Liver Injury Rats

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (8)

Background: Cuscutae Semen (CS) is reported to show a hepatoprotective effect. Chlorogenic acid, hyperoside and astragalin are three major biologicall......

Evaluating Pharmacokinetic and Distribution Characteristics for A New Antitumor Activity Ortho-aryl Chalcone Compound of OC26 in Rats by LC-MS/MS Method

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (7)

Introduction: OC26, an ortho-aryl chalcone compound, shows excellent antitumor activity in vitro and vivo. However, the pharmacokinetic characteristic......

An UHPLC-UV Method for the Determination of Vancomycin in Human Serum

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (7)

Objective: To develop a rapid ultra-performance liquid chromatographic (UHPLC)-UV method for vancomycin determination in human serum for therapeutic d......

Metabolic Changes in Mouse Plasma after Acute Diquat Poisoning by UPLC-MS/MS

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (7)

Introduction: Diquat is a fast-acting contact herbicide and plant dehydrating agent. The oral lethal dose 50 (LD50) of diquat in mice is about 125 mg/......

A Validated LC-MS/MS Method for the Determination of Mezlocillin in Plasma: An Adapted Method for Therapeutic Drug Monitoring in Children

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (7)

Background: Mezlocillin is off-label used for the treatment of respiratory infections in children. Therapeutic Drug Monitoring (TDM) data are also lim......

Content and Composition of Phospholipids, Fatty Acids and Sterols in Commercial Natural Phospholipid Excipients

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (7)

Background: Phospholipids are widely used in food and pharmaceutical industry as functional excipients. In spite of the many analytical methods report......

Simultaneous Determination of Seven Active Components in Desheng Pills by High-performance Liquid Chromatography

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (1)

Background: Desheng pills (DSP) consist of six traditional Chinese medicine. This preparation is used fornourishing blood, eliminating stasis, soothin......

A Sensitive HPLC-MS/MS Method for the Quantification of Selegiline Beagle Dog Plasma: Application to a Pharmacokinetic Study

期刊: CURRENT PHARMACEUTICAL ANALYSIS, 2021; 17 (1)

Objective: To develop a reliable and sensitive high-performance liquid chromatographytandem mass spectrometry (HPLC-MS/MS) method for the quantificati......

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