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TRPM2 channel in oxidative stress-induced mitochondrial dysfunction and apoptotic cell death

期刊: APOPTOSIS IN HEALTH AND DISEASE, PT A, 2021; 125 ()

Mitochondria, conserved intracellular organelles best known as the powerhouse of cells for generating ATP, play an important role in apoptosis. Oxidat......

Dual roles of ATP-binding site in protein kinases: Orthosteric inhibition and allosteric regulation

期刊: ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 124: PROTEIN KINASES IN DRUG DISCOVERY, 2021; 124 ()

Protein kinases use ATP to phosphorylate other proteins. Phosphorylation (p) universally orchestrates a fine-tuned network modulating a multitude of b......

Biological functions and clinical implications of interleukin-34 in inflammatory diseases

期刊: INFLAMMATORY DISORDERS, PT A, 2020; 119 ()

Interleukin (IL)-34 is a recently discovered cytokine and ligand of the colony-stimulating factor (CSF)-1 receptor. Although CSF-1 and IL-34 share sim......

Roles of Porphyromonas gingivalis and its virulence factors in periodontitis

期刊: INFLAMMATORY DISORDERS - PT B, 2020; 120 ()

Periodontitis is an infection-driven inflammatory disease, which is characterized by gingival inflammation and bone loss. Periodontitis is associated ......

lTargeting FOXP3 complex ensemble in drug discovery

期刊: ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 121, 2020; 121 ()

Forkhead Box P3 (FOXP3) is a key transcriptional regulator of regulatory T cells (Tregs), especially for its function of immune suppression. The speci......

Role of protein-protein interactions in allosteric drug design for DNA methyltransferases

期刊: ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 121, 2020; 121 ()

DNA methyltransferases (DNMTs) not only play key roles in epigenetic gene regulation, but also serve as emerging targets for several diseases, especia......

Smart Cell-Penetrating Peptide-Based Techniques for Intracellular Delivery of Therapeutic Macromolecules

期刊: THERAPEUTIC PROTEINS AND PEPTIDES, 2018; 112 ()

Many therapeutic macromolecules must enter cells to take their action. However, their treatment outcomes are often hampered by their poor transportati......

JIF:3.78

Chromatin Remodeling and Plant Immunity

期刊: CHROMATIN REMODELLING AND IMMUNITY, 2017; 106 ( )

Chromatin remodeling, an important facet of the regulation of gene expression in eukaryotes, is performed by two major types of multisubunit complexes......

JIF:2.44

The Functional Stability of FOXP3 and ROR gamma t in Treg and Th17 and Their Therapeutic Applications

期刊: CHROMATIN PROTEINS AND TRANSCRIPTION FACTORS AS THERAPEUTIC TARGETS, 2017; 107 ( )

The balance of CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imb......

JIF:2.44

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