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Dual roles of ATP-binding site in protein kinases: Orthosteric inhibition and allosteric regulation

Li, MY; Rehman, AU; Liu, YQ; Chen, K; Lu, SY

Lu, SY (corresponding author), Shanghai Jiao Tong Univ, Key Lab Cell Differentiat & Apoptosis, Chinese Minist Educ, Dept Pathophysiol,Sch Med, Shanghai, Peoples R China.; Lu, SY (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Med Chem & Bioinformat Ctr, Shanghai, Peoples R China.; Chen, K (corresponding author), Naval Mil Med Univ, Changhai Hosp, Dept Orthoped, Shanghai, Peoples R China.

ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 124: PROTEIN KINASES IN DRUG DISCOVERY, 2021; 124 (): 87

Abstract

Protein kinases use ATP to phosphorylate other proteins. Phosphorylation (p) universally orchestrates a fine-tuned network modulating a multitude of b......

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